214894-89-0

Basic information

• Product Name: 5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%
• Synonyms: 5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine;5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%;5-(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine;5-(bromomethyl)-2,3-dihydro-1,4-Benzodioxin
• CAS NO: 214894-89-0
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.07056
• Mol File: 214894-89-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 69.4℃
• Boiling Point: 295.7°C at 760 mmHg
• Flash Point: 137.9°C
• Appearance: /
• Density: 1.549g/cm³
• Vapor Pressure: 0.00265mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%(214894-89-0)
• EPA Substance Registry System: 5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97%(214894-89-0)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 214894-89-0(Hazardous Substances Data)

Usage

General Description

5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine is a chemical compound with a purity of 97%. It is a benzodioxine derivative containing a bromomethyl group attached to the 5th position of the benzene ring. 5-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE,97% is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is important to handle this chemical with caution as it is a potentially hazardous material and should be stored and used in a controlled environment following proper safety protocols.

InChI:InChI=1/C9H9BrO2/c10-6-7-2-1-3-8-9(7)12-5-4-11-8/h1-3H,4-6H2

Upstream product

• 33632-34-7 5-methyl-2,3-dihydrobenzo[b][1,4]dioxine 
• 274910-19-9 (2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanol 
• 4442-53-9 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid 
• 488-17-5 3-methylbenzene-1,2-diol 

Downstream Products

• 261633-71-0 2,3-dihydro-1,4-benzodioxin-5-methanamine 

Relevant articles and documents

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

Replacing the naphthalene C-unit of the anti-tuberculosis drug bedaquiline with a range of bicyclic heterocycles of widely differing lipophilicity gave analogs with a 4.5-fold range in clogP values. The biological results for these compounds indicate on average a lower clogP limit of about 5.0 in this series for retention of potent inhibitory activity (MIC90s) against M.tb in culture. Some of the compounds also showed a significant reduction in inhibition of hERG channel potassium current compared with bedaquiline, but there was no common structural feature that distinguished these.

Substituted oxygenated heterocycles and thio-analogues: Synthesis and biological evaluation as melatonin ligands

A new series of substituted oxygenated heterocycles and thio-analogues were synthesized and evaluated as melatonin receptor ligands. The replacement of the indolic moiety of melatonin by heterocyclic skeleton such as 1,4- benzodioxin, 2,3-dihydro-1,4-benzodioxin, chroman, 2,3-dihydro-1,4- benzoxathiin, thiochroman, carrying the amidic chain on the aromatic ring, leads to compounds showing a weak affinity for melatonin receptors, except for the compounds 1cb and 1hb. (C) 2000 Elsevier Science Ltd.