215099-32-4

Basic information

• Product Name: Carbamic acid, [4-(2-aminoethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [4-(2-aminoethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 215099-32-4
• Molecular Formula: C10H17N3O2S
• Molecular Weight: 243.33
• Mol File: 215099-32-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.231g/cm3 (Cal.)
• CAS DataBase Reference: Carbamic acid, [4-(2-aminoethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-(2-aminoethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)(215099-32-4)
• EPA Substance Registry System: Carbamic acid, [4-(2-aminoethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)(215099-32-4)

Safety Data

• Hazardous Substances Data: 215099-32-4(Hazardous Substances Data)

Upstream product

• 147284-02-4 tert-butyl 4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 408365-95-7 2-{2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}ethyl 4-methylbenzenesulfonate 
• 82548-78-5 ethyl {2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}acetate 
• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein

Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the molecule is deputed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. This binding hypothesis was verified by molecular dynamics simulations, while the linkage between these two pharmacophores was found to enhance antiretroviral activity both on the wild-type virus and on HIV-1 strains with resistance to currently licensed drugs. The two most interesting compounds 6 and 13 showed no cytotoxicity, thus becoming valuable leads for further investigations.