215099-82-4Relevant articles and documents
Synthesis of N-phosphoryl amino acids via phosphoramidite amine-exchange
Chow, Chun P.,Berkman, Clifford E.
, p. 7471 - 7474 (1998)
N-Phosphoryl amino acids were prepared rapidly and in high yield via phosphoramidite amine-exchange in the presence of 1H-tetrazole followed by oxidation with mCPBA. Formation of dibenzyl phosphoramidates incorporating the representative C-terminal protected amino acids leucine, phenylalanine, glutamic acid, and proline were demonstrated to be most successful with dibenzyl N,N-dimethylphosphoramidite although the N,N-diethyl and N,N- diisopropyl analogs also provided high yields.
