215253-76-2

Basic information

• Product Name: 2-(CHLOROMETHYL)-3-METHOXYPYRIDINE
• Synonyms: 2-(CHLOROMETHYL)-3-METHOXYPYRIDINE
• CAS NO: 215253-76-2
• Molecular Formula: C7H8ClNO
• Molecular Weight: 157.5975
• Mol File: 215253-76-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 225.616 °C at 760 mmHg
• Flash Point: 90.25 °C
• Appearance: /
• Density: 1.173 g/cm³
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(CHLOROMETHYL)-3-METHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-3-METHOXYPYRIDINE(215253-76-2)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-3-METHOXYPYRIDINE(215253-76-2)

Safety Data

• Hazardous Substances Data: 215253-76-2(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-3-methoxypyridine is a chemical compound with the molecular formula C7H8ClNO. It is a pyridine derivative with a chloromethyl group and a methoxy group attached to the third and second carbon atoms, respectively. 2-(Chloromethyl)-3-methoxypyridine is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its versatile reactivity and plays a crucial role in the production of various advanced materials. However, it is important to handle this compound with caution, as it is classified as a hazardous material due to its potential toxicity and flammability.

InChI:InChI=1/C7H8ClNO/c1-10-7-3-2-4-9-6(7)5-8/h2-4H,5H2,1H3

Upstream product

• 35392-65-5 3-methoxy-2-methylpyridine 1-oxide 
• 20928-63-6 3-methoxy-1H-pyridin-2-one 
• 52605-96-6 2-chloro-3-methoxypyridine 
• 26395-26-6 3-methoxy-2-methylpyridine 
• 51984-46-4 2-Hydroxymethyl-3-methoxy pyridine 

Downstream Products

• 149489-09-8 2-(3-methoxypyridin-2-yl)acetonitrile 

Relevant articles and documents

Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP PDE5) for the treatment of sexual dysfunction

Compounds of formulae (IA) and (IB) or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein R1 is C1 to C3 alkyl substituted with C3 to C6 cycloalkyl, CONR5R6 or a N-linked heterocyclic group; (CH2)nHet or (CH2)nAr; R2 is C1 to C6 alkyl; R3 is C1 to C6 alkyl optionally substituted with C1 to C4 alkoxy; R4 is SO2NR7R8; R5 and R6 are each independently selected from H and C1 to C4 alkyl optionally substituted with C1 to C4 alkoxy, or, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic group; R7 and R8, together with the nitrogen atom to which they are attached, form a 4-R10-piperazinyl group; R10 is H or C1 to C4 alkyl optionally substituted with OH, C1 to C4 alkoxy or CONH2; H is an optionally substituted C-linked 5- or 6-membered heterocyclic group; Ar is optionally substituted phenyl; and n is 0 or 1; are potent and selective cGMP PDE5 inhibitors useful in the treatment of, inter alia, male erectile dysfunction and female sexual dysfunction.

SYNTHESES OF A NATURALLY OCCURRING HYDROXAMIC ACID AND ITS ANALOGUES

A naturally occurring cyclic hydroxamic acid, isolated from Pseudomonas species, and its analogues were synthesized via six steps starting from 2-hydroxy-3-methoxypyridine.The antimicrobial activity of the synthesized compounds is described.