21531-91-9 Usage
Description
1,3-Hexanediol, also known as Hexane-1,3-diol, is a diol compound with a six-carbon chain and two hydroxyl groups attached to the first and third carbon atoms. It is a colorless liquid with a mild odor and is soluble in water. Its chemical structure allows it to form hydrogen bonds and interact with various molecules, making it a versatile compound with potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
1,3-Hexanediol is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to form hydrogen bonds and interact with other molecules makes it a valuable component in the development of new drugs.
Used in the Preparation of Dual Peroxisome Proliferator-Activated Receptors (PPAR) γ and δ Agonists:
1,3-Hexanediol is used as a starting material for the preparation of dual PPAR γ and δ agonists, which are novel euglycemic agents. These compounds help regulate blood sugar levels and are being investigated for their potential in treating type 2 diabetes. The use of 1,3-Hexanediol in this application is due to its ability to form stable and bioactive compounds with reduced weight gain profiles, making it a promising candidate for the development of safer and more effective treatments for diabetes.
Synthesis Reference(s)
Tetrahedron Letters, 27, p. 3377, 1986 DOI: 10.1016/S0040-4039(00)84800-5
Check Digit Verification of cas no
The CAS Registry Mumber 21531-91-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,5,3 and 1 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 21531-91:
(7*2)+(6*1)+(5*5)+(4*3)+(3*1)+(2*9)+(1*1)=79
79 % 10 = 9
So 21531-91-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H14O2/c1-2-3-6(8)4-5-7/h6-8H,2-5H2,1H3
21531-91-9Relevant articles and documents
Oxygen-directed intramolecular hydroboration
Rarig, Robert-Andre F.,Scheideman, Matthew,Vedejs, Edwin
supporting information; body text, p. 9182 - 9183 (2009/02/03)
Metal-free homoallylic oxygen-directed intramolecular hydroboration is reported. Regioselectivities from 20:1 to 82:1 favoring the 1,3-dioxy-substituted products have been achieved using Me2S·BH3/TfOH followed by standard oxidative workup. Branching at the C5 position improves regioselectivity. Copyright
Regioselective Opening of Epoxy Alcohols: Mild Chemo- and Stereoselective Preparation of Iodohydrins and 1,2-Diols
Bonini, Carlo,Righi, Giuliana,Sotgiu, Giovanni
, p. 6206 - 6209 (2007/10/02)
Several 2,3-epoxy alcohols have been opened, at -60 deg C, with MgI2, leading to the corresponding 3-iodo 1,2-diols with a high level of regio- and chemoselectivity.The iodohydrins can be reduced "in situ", by means of nBu3SnH, to the corresponding 1,2-diols.The chemo-, regio-, and stereocontrol of the reaction makes the method of wide use.Furthermore, epoxy alcohol derivatives (acetyl, benzyl, or TBMS) still maintain a strong preference for C-3 attack of the nucleophile.The experimental data strongly suggest that a metal (Mg) centered chelate is formed throughout the reaction, which gives rise to the regioselective delivery of the iodiode ion.
