21537-95-1

Basic information

• Product Name: 3-Bromo-s-triazolo[3,4-a]phthalazine
• Synonyms: 3-Bromo-1,2,4-triazolo[3,4-a]phthalazin;3-Bromo-s-triazolo[3,4-a]phthalazine;3-Bromo-1,2,4-triazolo[3,4-α]phthalazine;3-Bromo-s-triazolo[3,4-α]phthalazine;3-Bromo-1,2,4-triazolo[3,4-a]phthalazine
• CAS NO: 21537-95-1
• Molecular Formula: C9H5BrN4
• Molecular Weight: 249.07
• Product Categories: Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Heterocycles, Nucleotides, Bases & Related Reagents
• Mol File: 21537-95-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 206-2080C
• Appearance: /
• Density: 1.92±0.1 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: -1.35±0.30(Predicted)
• CAS DataBase Reference: 3-Bromo-s-triazolo[3,4-a]phthalazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-s-triazolo[3,4-a]phthalazine(21537-95-1)
• EPA Substance Registry System: 3-Bromo-s-triazolo[3,4-a]phthalazine(21537-95-1)

Safety Data

• Hazardous Substances Data: 21537-95-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Upstream product

• 234-80-0 1,2,4-triazolo[3,4-a]phthalazine 

Relevant articles and documents

Triazolophthalazines: Easily Accessible Compounds with Potent Antitubercular Activity

Tuberculosis (TB) remains one of the major causes of death worldwide, in particular because of the emergence of multidrug-resistant TB. Herein we explored the potential of an alternative class of molecules as anti-TB agents. Thus, a series of novel 3-substituted triazolophthalazines was quickly and easily prepared from commercial hydralazine hydrochloride as starting material and were further evaluated for their antimycobacterial activities and cytotoxicities. Four of the synthesized compounds were found to effectively inhibit the Mycobacterium tuberculosis (M.tb) H37Rv strain with minimum inhibitory concentration (MIC) values -1, whereas no compounds displayed cytotoxicity against HCT116 human cell lines (IC50>100 μm). More remarkably, the most potent compounds proved to be active to a similar extent against various multidrug-resistant M.tb strains, thus uncovering a mode of action distinct from that of standard antitubercular agents. Overall, their ease of preparation, combined with their attractive antimycobacterial activities, make such triazolophthalazine-based derivatives promising leads for further development. Old trick, new drugs: A series of triazolophthalazines were synthesized and evaluated as potential antitubercular agents. A number of these easy-to-prepare compounds proved to be highly potent inhibitors of Mycobacterium tuberculosis (M.tb) and exhibited similar potency against multidrug-resistant M.tb strains.