215453-39-7Relevant articles and documents
Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors
Rewinkel,Lucas,Smit,Noach,Van Dinther,Rood,Jenneboer,Van Boeckel
, p. 2837 - 2842 (2007/10/03)
Replacement of the highly basic benzamidine moiety with moderate basic amino-bicycloaryl moieties in a series of thrombin inhibitors related to NAPAMP provided potent enzyme inhibition and significant improvements in membrane transport and oral bioavailability.