215512-35-9

Basic information

• Product Name: [N'-Benzyloxycarbonyl-N-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazino]-acetic acid ethyl ester
• Synonyms: [N'-Benzyloxycarbonyl-N-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazino]-acetic acid ethyl ester
• CAS NO: 215512-35-9
• Molecular Weight: 499.564
• Mol File: 215512-35-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [N'-Benzyloxycarbonyl-N-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazino]-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [N'-Benzyloxycarbonyl-N-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazino]-acetic acid ethyl ester(215512-35-9)
• EPA Substance Registry System: [N'-Benzyloxycarbonyl-N-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazino]-acetic acid ethyl ester(215512-35-9)

Safety Data

• Hazardous Substances Data: 215512-35-9(Hazardous Substances Data)

Upstream product

• 4503-58-6 benzyl 2-(2-ethoxy-2-ethoxyethyl)-1-hydrazinecarboxylate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 215512-38-2 (S)-2-[(2S,3S)-2-((S)-2-{2-[N'-Benzyloxycarbonyl-N-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazino]-acetylamino}-3-phenyl-propionylamino)-3-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester 
• 215512-37-1 (S)-2-((2S,3S)-2-{2-[N'-Benzyloxycarbonyl-N-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazino]-acetylamino}-3-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester 
• 215512-36-0 [N'-Benzyloxycarbonyl-N-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazino]-acetic acid 

Relevant articles and documents

Synthesis and activity of HIV protease inhibitors

We report here the synthesis and activity of HIV protease inhibitors. In the first stage hydrophobic compounds incorporating a 'carba' bond surrogate or a beta-homologated residue were synthesized. Secondly, we synthesized cyclic compounds in which we incorporated 2-quinoline carboxylic acid in the P3 position and the amino-hydroxyindane moiety in the P'3. The last part of this work was dedicated to a structure/activity study of a peptide substrate. These modifications allowed us to work up the synthesis of new pseudopeptide bonds: amino-amide and hydroxy-amide. Compounds with activity in the micromolar range were actually a starting point for the synthesis of new protease inhibitors.