215589-24-5

Basic information

• Product Name: 4-(4-FLUOROPHENOXY)BENZONITRILE
• Synonyms: 4-(4-FLUOROPHENOXY)BENZENECARBONITRILE;4-(4-FLUOROPHENOXY)BENZONITRILE;4-CYANO-4'-FLUORODIPHENYL ETHER;AKOS B035621;4-(4-Fluorophenoxy)
• CAS NO: 215589-24-5
• Molecular Formula: C₁₃H₈FNO
• Molecular Weight: 213.21
• Mol File: 215589-24-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 69 °C
• Boiling Point: 322.8°C at 760 mmHg
• Flash Point: 149°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000272mmHg at 25°C
• Refractive Index: 1.591
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-(4-FLUOROPHENOXY)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-FLUOROPHENOXY)BENZONITRILE(215589-24-5)
• EPA Substance Registry System: 4-(4-FLUOROPHENOXY)BENZONITRILE(215589-24-5)

Safety Data

• Hazardous Substances Data: 215589-24-5(Hazardous Substances Data)

Usage

Description

4-(4-FLUOROPHENOXY)BENZONITRILE is an organic compound with the molecular formula C13H8FNO2. It is a derivative of benzonitrile, featuring a fluorophenoxy group attached to the 4-position of the benzene ring. 4-(4-FLUOROPHENOXY)BENZONITRILE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
4-(4-FLUOROPHENOXY)BENZONITRILE is used as a reactant for the preparation of 1,2,4-Oxadiazol-5-yl benzenesulfonamides. These compounds are potent and selective inhibitors of cytosolic hCA II, which are important targets for the development of novel drugs in various therapeutic areas, such as hypertension, glaucoma, and epilepsy.
Used in Chemical Synthesis:
In the chemical industry, 4-(4-FLUOROPHENOXY)BENZONITRILE can be utilized as an intermediate for the synthesis of various complex organic molecules, including pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structural features make it a valuable building block for the development of new compounds with diverse applications.

InChI:InChI=1/C13H8FNO/c14-11-3-7-13(8-4-11)16-12-5-1-10(9-15)2-6-12/h1-8H

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 767-00-0 4-cyanophenol 
• 459-57-4 4-fluorobenzaldehyde 
• 371-41-5 4-Fluorophenol 
• 619-72-7 4-nitrobenzonitrile 
• 3058-39-7 4-iodobenzonitrile 
• 58995-64-5 1-(N,N-dimethylaminomethyl)-3,4-(methylenedioxy)benzene 
• 106544-63-2 (2-((tert-butyldimethylsiloxy)methyl)-3,4-(methylenedioxy)benzyl)trimethylsilane 
• 106544-64-3 2,3-(methylenedioxy)-6-((trimethylsilyl)methyl)benzyl iodide 
• 116351-52-1 2,3-(methylenedioxy)-6-((trimethylsilyl)methyl)benzyl chloride 
• 623-00-7 4-bromobenzenecarbonitrile 
• 1194-02-1 4-fluorobenzonitrile 
• 106544-66-5 2-(2,3-(methylenedioxy)-6-((trimethylsilyl)methyl)benzyl)-6,7-(methylenedioxy)-3,4-dihydroisoquinolinium perchlorate 

Downstream Products

• 1443126-37-1 5-[4-(4-fluorophenoxy)phenyl]-N,N-dimethyl-2H-tetrazole-2-carboxamide 
• 1443126-23-5 5-(4-(4-fluorophenoxy)phenyl)-1H-tetrazole 
• 361436-91-1 4-(4-fluorophenoxy)benzamidine acetate 
• 299206-79-4 2-[4-(4-Fluorophenoxy)phenyl]-1H-imidazole 
• 215589-52-9 N-<4-(4-fluorophenoxy)benzyl>tetrahydropyran-4-ylamine 
• 501667-16-9 6-[4-(4-fluoro-phenoxy)-phenyl]-4-morpholin-4-yl-pyridine-2-carboxylic acid methyl ester 
• 501667-14-7 4-{2-[4-(4-fluorophenoxy)phenyl]-6-methyl-pyridine-4-yl}morpholine 
• 361437-12-9 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid 
• 361437-13-0 4-Methoxy-6-[4-(4-fluorophenoxy)phenyl]pyridine-2-carboxylic acid methyl ester 

Relevant articles and documents

COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME

The present invention provides a compound represented by chemical formula 1 and an organic light emitting device comprising the same. The organic light emitting device including the compound has excellent electrochemical and thermal stability, and thus has excellent lifespan characteristics.

Synthesis of copper nanoparticles supported on a microporous covalent triazine polymer: An efficient and reusable catalyst for O-arylation reaction

Copper nanoparticles were supported on a microporous covalent triazine polymer prepared by the Friedel-Crafts reaction (Cu@MCTP-1). The resulting material was characterized by powder X-ray diffraction, thermogravimetric analysis, N2 adsorption-desorption isotherms at 77 K, transmission electron microscopy, X-ray photoelectron spectroscopy, and inductively coupled plasma optical emission spectroscopy, and Cu particles with an average size of 3.0 nm and a BET total surface area of ca. 1002 m2 g-1 were obtained. Cu@MCTP-1 was evaluated as a heterogeneous catalyst for the Ullmann coupling of O-arylation over a series of aryl halides and phenols without employing expensive ligands or inert atmosphere, which produced an excellent yield of the corresponding diaryl ethers. The catalyst could be recovered by simple centrifugation and was reusable at least five times with only a slight decrease in catalytic activity.

Design and Synthesis of a Focused Library of Diamino Triazines as Potential Mycobacterium tuberculosis DHFR Inhibitors

We report design of a series of 2,4-diamino triazines as Mycobacterium tuberculosis (Mtb) dihydrofolate reductase inhibitors. The synthesized compounds were evaluated against Mtb (H37Rv and Dormant stage H37Ra), their cytotoxicity was assessed (HepG2 and A549 cell lines), and selectivity toward Mtb was evaluated by testing against other bacterial strains. Some derivatives showed promising activity along with low cytotoxicity. The most potent compound in the whole cell assay (MIC 0.325 μM against H37Rv) showed selectivity in the enzyme assay and exhibited synergy with second line anti-TB agent p-amino salicylic acid. This study therefore provides promising molecules for further development as antituberculosis DHFR inhibitors.