21577-80-0

Basic information

• Product Name: dodecyl hydrogen phthalate
• Synonyms: dodecyl hydrogen phthalate;Phthalic acid hydrogen 1-dodecyl ester;1,2-Benzenedicarboxylic acid, monododecyl ester;Einecs 244-450-8;Monododecyl phthalate;1,2-Benzenedicarboxylic Acid 1-Dodecyl Ester;Dodecyl Phthalate;Lauryl Phthalate
• CAS NO: 21577-80-0
• Molecular Formula: C₂₀H₃₀O₄
• Molecular Weight: 334.4498
• EINECS: 244-450-8
• Product Categories: Aromatics;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 21577-80-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 49.5-50.0 °C
• Boiling Point: 464.8°Cat760mmHg
• Flash Point: 155.5°C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 1.94E-09mmHg at 25°C
• Refractive Index: 1.508
• PKA: 3.38±0.36(Predicted)
• CAS DataBase Reference: dodecyl hydrogen phthalate(CAS DataBase Reference)
• NIST Chemistry Reference: dodecyl hydrogen phthalate(21577-80-0)
• EPA Substance Registry System: dodecyl hydrogen phthalate(21577-80-0)

Safety Data

• Hazardous Substances Data: 21577-80-0(Hazardous Substances Data)

Usage

Description

Dodecyl hydrogen phthalate, also known as dodecyl phthalate, is a chemical compound derived from the phthalic acid ester family. It is characterized by its hydrophobic nature and is commonly used in various industrial applications due to its unique properties.

Uses

Used in Pharmaceutical Industry:
Dodecyl hydrogen phthalate is used as a key component in the preparation of Cytarabine (C998100) derivatives, which are potent anticancer agents. Its incorporation in the synthesis process aids in enhancing the drug's efficacy and targeting cancer cells more effectively.

InChI:InChI=1/C20H30O4/c1-2-3-4-5-6-7-8-9-10-13-16-24-20(23)18-15-12-11-14-17(18)19(21)22/h11-12,14-15H,2-10,13,16H2,1H3,(H,21,22)

Upstream product

• 85-44-9 phthalic anhydride 
• 112-53-8 1-dodecyl alcohol 

Downstream Products

• 1188923-02-5 dodecyl 2-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)benzoate 
• 139049-98-2 2-Hydroperoxycarbonyl-benzoic acid dodecyl ester 
• 23761-34-4 phthalic acid butyl ester-dodecyl ester 

Relevant articles and documents

A surfactant

The invention discloses a surfactant for driving oil. The surfactant is prepared through the following method. The method comprises steps: first, an intermediate myristyl allyl dibromo tetramethyl ethylenediamine is synthesized; second, myristyl allyl dibromo tetramethyl ethylenediamine is synthesized. The intermediate is dissolved completely in ethyl acetate, the constant temperature of 50-60 DEG C is achieved, 3-bromopropylene is added in the reaction system, after the reaction is carried out at a constant temperature with stirring for 4h, pressure reduction pumping filtration is carried out, and white solid is obtained. The white solid is subjected to recrystallization for two times by utilization of ether, drying is carried out until a constant weight is achieved, and the surfactant for driving oil is prepared. Myristyl allyl dibromo tetramethyl ethylenediamine also can be compounded with sodium phthalate of mono lauryl alcohol according to a weight ratio of 1:0.2-1, and a compound surfactant for driving oil is obtained. The synthesis technology conditions are simple, products are easy to separate, the yield is high, and industrialization is easy. Performances of the product such as salt resistance, temperature resistance, foaming property and foam stability, oil water interface tension force and the like are better than that of a traditional surfactant for driving oil.

Prodrugs Based on Gemcitabine Structure and Synthetic Methods and Applications Thereof

Prodrugs based on gemcitabine structure shown in formula (I) as well as their synthetic method and application are disclosed in the present invention, wherein the definitions for the groups of a, b, c, d, E, Z and V are described in the specification. By modifying the N4 group, the solubility, the bioavailability and the organ specificity of the prodrugs are improved. Therefore, the fast metabolism problem is overcome for the produced prodrugs compounds. Intestinal toxicity induced by gemcitabine is decreased. Thereby, the prodrugs can be delivered by oral administration in clinics and further improve their anti-tumor, anti-cancer, anti-infection and diffusion preventing capability, and can also specifically act on liver or colon. The synthetic method is simple and adapted to industrial production.

NOUVEAUX DECONTAMINANTS. ACTION DES PERACIDES A GROUPE ESTER SUR QUELQUES TOXIQUES INSECTICIDES OU DE GUERRE

A new peroxyacid-ester series has been obtained and used in the destruction of toxic agents.These structures oROCOC6H4CO3H and ROCO(CH2)nCO3H are more stable than the unsubstituted compounds.The reaction with paraoxon (O,O-diethyl O-paranitrophenylphosphate) and HD (2,2'-dichlorodiethylsulfide) goes to completion in a very short time.The influence of the R group and the length of the chain (n=2......12) has been studied.The addition of some long chain tetraalkyl-ammonium salts enhances the rate of the reaction by micellar catalysis.