215788-34-4

Basic information

• Product Name: 5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
• Synonyms: 5-TRIFLUOROMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HCL;5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;5-Trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 215788-34-4
• Molecular Formula: C₁₀H₁₀F₃N
• Molecular Weight: 237.65
• Mol File: 215788-34-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 217.4 °C at 760 mmHg
• Flash Point: 85.3 °C
• Appearance: /
• Density: 1.213 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.97±0.20(Predicted)
• CAS DataBase Reference: 5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(215788-34-4)
• EPA Substance Registry System: 5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(215788-34-4)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 215788-34-4(Hazardous Substances Data)

Usage

General Description

"5-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride" is a chemical compound that belongs to the class of tetrahydroisoquinoline derivatives. It features a trifluoromethyl group attached to the tetrahydroisoquinoline ring structure. 5-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE is typically found in the form of a crystalline powder and is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties make it a valuable intermediate in the production of a wide range of chemical substances. Additionally, it can also be utilized in research and development applications for the investigation of its potential biological and pharmacological activities.

InChI:InChI=1/C10H10F3N.ClH/c11-10(12,13)9-3-1-2-7-6-14-5-4-8(7)9;/h1-3,14H,4-6H2;1H

Upstream product

• 215794-20-0 2,2,2-trifluoro-1-[5-(trifluoromethyl)-3,4-dihydro Isoquinoline-2(1H)-yl]ethane-1-one 
• 215797-90-3 2,2,2-trifluoro-N-(2-(2-(trifluoromethyl)phenyl)ethyl)acetamide 
• 774-18-5 2-(2-(trifluoromethyl)phenyl)ethan-1-amine 
• 27810-64-6 isoquinoline-5-carboxylic acid 

Downstream Products

• 1028330-57-5 C₃₀H₃₃F₃N₂O 

Relevant articles and documents

Synthesis method of 5-trifluoromethyl isoquinoline-8-formic acid

The invention discloses a synthesis method of 5-trifluoromethyl isoquinoline-8-formic acid. The method comprises the steps of by using 4-trifluoromethyl phenylethylamine as a raw material, carrying out amino protection, cyclization, hydrolysis, brominatio

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.