216060-23-0

Basic information

• Product Name: 4-(PYRAZIN-2-YL)BENZOIC ACID
• Synonyms: 4-(PYRAZIN-2-YL)BENZOIC ACID;4-(3,6-Dimethylpyrazin-2-yl)benzoic acid;4-(3-Chloropyrazin-2-yl)benzoic acid;4-(5-Methylthiophen-2-yl)benzoic acid;4-(6-Aminopyrazin-2-yl)benzoic acid;4-(6-Chloropyrazin-2-yl)benzoic acid
• CAS NO: 216060-23-0
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.19342
• Product Categories: Carboxylic Acids;Phenyls & Phenyl-Het;Carboxylic Acids;Phenyls & Phenyl-Het
• Mol File: 216060-23-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 396.413 °C at 760 mmHg
• Flash Point: 193.544 °C
• Appearance: /
• Density: 1.303 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: 2-8°C
• PKA: 3.62±0.10(Predicted)
• CAS DataBase Reference: 4-(PYRAZIN-2-YL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRAZIN-2-YL)BENZOIC ACID(216060-23-0)
• EPA Substance Registry System: 4-(PYRAZIN-2-YL)BENZOIC ACID(216060-23-0)

Safety Data

• Hazardous Substances Data: 216060-23-0(Hazardous Substances Data)

Usage

General Description

4-(pyrazin-2-yl)benzoic acid is a chemical compound with a molecular formula C12H8N2O2. It consists of a benzene ring attached to a pyrazine ring and a carboxylic acid group. 4-(PYRAZIN-2-YL)BENZOIC ACID is a potential building block in organic synthesis and is commonly used in the pharmaceutical industry to develop new drugs. It has various applications in medicinal chemistry and drug discovery, and its derivatives are known to have anti-inflammatory and anticancer properties. Additionally, 4-(pyrazin-2-yl)benzoic acid is also used as a reagent in chemical reactions and as a research tool in molecular biology.

InChI:InChI=1/C11H8N2O2/c14-11(15)9-3-1-8(2-4-9)10-7-12-5-6-13-10/h1-7H,(H,14,15)

Upstream product

• 14508-49-7 2-chloropyrazin 
• 14047-29-1 4-carboxyphenylboronic acid 
• 466634-84-4 4-pyrazin-2-yl benzoic acid methyl ester 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 87199-17-5 4-formylphenylboronic acid, 
• 127406-08-0 4-pyrazin-2-yl-benzaldehyde 

Downstream Products

• 1354353-58-4 N-(4-(2-methylpyridin-4-yl)benzyl)-4-(pyrazin-2-yl)benzamide 
• 1441810-67-8 C₄₁H₄₀N₄O₅ 
• 1354353-79-9 4-(pyrazin-2-yl)-N-(4-(2-(trifluoromethyl)pyridin-4-yl)benzyl)benzamide 
• 1354353-71-1 N-(2'-fluoro-(2,4'-bipyridinl-5-yl)methyl)-4-(pyrazin-2-yl)benzamide 
• 1354353-66-4 N-(3-fluoro-4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl)-4-(pyrazin-2-yl)benzamide 
• 1354353-59-5 N-((2'-methyl-[2,4'-bipyridin]-5-yl)methyl)-4-(pyrazin-2-yl)benzamide 
• 1354354-39-4 N-((3-methyl-2'-(trifluoromethyl)-2,4'-bipyridin-5-yl)methyl)-4-(pyrazin-2-yl)benzamide 

Relevant articles and documents

KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands

Seventeen biarylcarboxybenzamide derivatives were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor (VR1) in rat DRG neurons. The replacement of the piperazine moiety of the lead compound 1 with phenyl ring showed quite enhanced antagonistic activity. Among the prepared derivatives, N-(4-tert-butylphenyl)-4-pyridine-2-yl-benzamide (2, IC 50 = 31 nM) and N-(4-tert-butylphenyl)-4-(3-methylpyridine-2-yl) benzamide (3g, IC50 = 31 nM), showed 5-fold higher antagonistic activity than 1 in 45Ca2+-influx assay.