21620-95-1

Basic information

• Product Name: 7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, acetate
• CAS NO: 21620-95-1
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol File: 21620-95-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, acetate(21620-95-1)
• EPA Substance Registry System: 7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, acetate(21620-95-1)

Safety Data

• Hazardous Substances Data: 21620-95-1(Hazardous Substances Data)

Upstream product

• 930-68-7 cyclohexenone 
• 115-11-7 isobutene 

Downstream Products

• 1089210-04-7 1-{[5-(N-(3,4-dichlorophenyl)-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-propane hydrochloride 
• 1089210-02-5 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride 
• 1089209-99-3 1-{[5-(N-methyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride 
• 1089210-06-9 1-([5-(N-((1R)-1,7,7-trimethyl-bicyclo[2.1.1]hept-2-yl)-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy)-2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-ethane 
• 1089758-83-7 1-{[5-(N-(3,4-dichlorophenyl)-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-propane 
• 1089209-48-2 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol hydrochloride 
• 1089209-37-9 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride 
• 1089758-84-8 1-{[5-(N-(3,4-dichlorophenyl)-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazin-1-yl]-ethane 
• 1089758-82-6 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane 
• 1089209-93-7 1-{[5-(N-methylsulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propane 
• 1089210-00-3 1-{[5-(N-isopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane 
• 1089209-87-9 1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol 
• 1089758-80-4 1-{[5-(N-methyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane 
• 1089209-76-6 2,3-dihydro-2,2-dimethyl-7-{3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide 

Relevant articles and documents

Synthesis of 2,3-dihydrobenzofurans by Mn(OAc)3-based oxidative cycloaddition of 2-cyclohexenones with alkenes. Synthesis of (±)-conocarpan

Oxidative cycloaddition of a 2-cyclohexenone or α-tetralone and an alkene with dried Mn(OAc)3 in benzene at 80-140 °C provides a general route to dihydrobenzofurans 15 and dihydronaphthofurans 17. Although the yields are modest, this one-pot reaction provides simple access to these compounds, which have previously been prepared by multistep routes. Oxidative cycloaddition of 2-cyclohexenones with β-methylstyrenes provides a new route to benzofuranoid neolignans, which was applied to the synthesis of conocarpan (22). The formation of 2-acetoxyhexanedioic acids 27 and 47 from acetoxylation of 2-cyclohexenones in HOAc, but not in benzene, opens up a new class of Mn(OAc)3 reactions and explains Watt and Demir's discovery that much higher yields of α'-acetoxy enones are obtained in benzene than in HOAc.