216311-57-8

Basic information

• Product Name: (R)-1-N-BENZYL-BETA-PROLINE
• Synonyms: (3R)-1-(Phenylmethyl)-3-pyrrolidinecarboxylic acid;3-Pyrrolidinecarboxylic acid, 1-(phenylmethyl)-, (3R)-
• CAS NO: 216311-57-8
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.255
• Mol File: 216311-57-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 343.1 °C at 760 mmHg
• Flash Point: 161.3 °C
• Appearance: /
• Density: 1.205 g/cm³
• Vapor Pressure: 2.76E-05mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• PKA: 3.83±0.20(Predicted)
• CAS DataBase Reference: (R)-1-N-BENZYL-BETA-PROLINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-N-BENZYL-BETA-PROLINE(216311-57-8)
• EPA Substance Registry System: (R)-1-N-BENZYL-BETA-PROLINE(216311-57-8)

Safety Data

• Hazardous Substances Data: 216311-57-8(Hazardous Substances Data)

Usage

General Description

"(R)-1-N-BENZYL-BETA-PROLINE" is a chemical compound used widely in research and industrial applications. It is categorized as an organic compound with a benzyl group attached to the nitrogen atom of the proline molecule. It exists in its 'R' optical isomer form, referring to its specific orientation and configuration structure. It's commonly used in the pharmaceutical industry and scientific research, particularly as a chiral auxiliary used in organic synthesis, such as the creation of more complex chemical compounds with a specific 3D structure. Its precise synthesis ensures optimal product yields and high selectivity. However, like most chemicals, it should be handle with precaution as exposure could potentially lead to health risks.

InChI:InChI=1/C12H15NO2/c14-12(15)11-6-7-13(9-11)8-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,14,15)/t11-/m1/s1

Upstream product

• 1412978-97-2 benzyl (R)-1-tert-butoxycarbonylpyrrolidine-3-carboxylate 
• 72925-16-7 (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid 
• 72580-54-2 (R)-⁽³⁾-pyrrolidinecarboxylic acid 
• 72580-53-1 (S)-(+)-3-pyrrolidinecarboxylic acid 
• 101385-90-4 (R)-N-benzyl-3-hydroxypyrrolidine 
• 159063-16-8 (S)-1-benzylpyrrolidine-3-carbonitrile 
• 5747-92-2 1-benzyl-3-carboethoxypyrrolidine 
• 72925-15-6 3-ethoxycarbonyl-pyrrolidine 
• 59378-87-9 pyrrolidine-3-carboxylic acid 
• 17012-21-4 1-benzylpyrrolidine-3-carboxylic acid methyl ester 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 79-10-7 acrylic acid 
• 114715-35-4 (R)-3-methanesulfonyloxy-1-(phenylmethyl)-pyrrolidine 
• 100-52-7 benzaldehyde 

Relevant articles and documents

ORGANIC ARSENIC-BASED TYPE II PYRUVATE KINASE INHIBITOR AS WELL AS PREPARATION METHOD THEREFOR AND USE THEREOF

Provided by the present invention are an organic arsenic-based type II pyruvate kinase inhibitor as well as a preparation method therefor and a use thereof. Specifically, a PKM2 inhibitor of the present invention is a compound represented by formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer or tautomer, a hydrate or a solvate thereof, wherein, X1, X2, R1, R2, R3, R4, R5 and n are as defined in the description. The compound of the present invention has a high inhibitory activity and high specificity for PKM2 and is well suited for the preparation of a drug inhibiting tumors by inhibiting a PKM2 pathway.

Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones

A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.

Angiotensin II antagonists

This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.