2164-09-2

Basic information

• Product Name: CHLORANOCRYL
• Synonyms: 3',4'-DICHLORO-2-METHYLACRYLANILIDE;CHLORANOCRYL;DICRYL(R);DMCA(R);N-(3,4-DICHLOROPHENYL)METHYL-ACRYLAMIDE;NIAGARA 4556;2-Propenamide, N-(3,4-dichlorophenyl)-2-methyl-;3,4-Dichloranilid kyseliny methakrylove
• CAS NO: 2164-09-2
• Molecular Formula: C₁₀H₉Cl₂NO
• Molecular Weight: 230.09
• Mol File: 2164-09-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 124-126℃
• Boiling Point: 375.5°C at 760 mmHg
• Flash Point: 180.9°C
• Appearance: /
• Density: 1.319
• Vapor Pressure: 7.75E-06mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• PKA: 12.22±0.70(Predicted)
• Water Solubility: 8mg/L(temperature not stated)
• CAS DataBase Reference: CHLORANOCRYL(CAS DataBase Reference)
• NIST Chemistry Reference: CHLORANOCRYL(2164-09-2)
• EPA Substance Registry System: CHLORANOCRYL(2164-09-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RTECS: AS4025000
• Hazardous Substances Data: 2164-09-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2164-09-2 differently. You can refer to the following data:
1. Herbicide.
2. Chloranocryl functions as a herbicide for agricultural purposes.

InChI:InChI=1/C10H9Cl2NO/c1-6(2)10(14)13-7-3-4-8(11)9(12)5-7/h3-5H,1H2,2H3,(H,13,14)

Upstream product

• 65925-77-1 3,4-dichloro-N-(2,3-epoxy-2-methylpropionyl)aniline 
• 95-76-1 m,p-dichloroaniline 
• 920-46-7 Methacryloyl chloride 
• 79-41-4 poly(methacrylic acid) 

Downstream Products

• 888071-98-5 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (3,4-dichloro-phenyl)-amide 
• 65925-77-1 3,4-dichloro-N-(2,3-epoxy-2-methylpropionyl)aniline 
• 888073-33-4 3-methyl-5-trifluoromethyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (3,4-dichloro-phenyl)-amide 

Relevant articles and documents

Design, synthesis, and in vivo SAR of a novel series of pyrazolines as potent selective androgen receptor modulators

A novel series of pyrazolines 2 have been designed, synthesized, and evaluated by in vivo screening as tissue-selective androgen receptor modulators (SARMs). Structure-activity relationships (SAR) were investigated at the R 1 to R6 positions as well as the core pyrazoline ring and the anilide linker. Overall, strong electron-withdrawing groups at the R 1 and R2 positions and a small group at the R5 and R6 position are optimal for AR agonist activity. The (S)-isomer of 7c exhibits more potent AR agonist activity than the corresponding (R)-isomer. (S)-7c exhibited an overall partial androgenic effect but full anabolic effect via oral administration in castrated rats. It demonstrated a noticeable antiandrogenic effect on prostate in intact rats with endogenous testosterone. Thus, (S)-7c is a tissue-selective nonsteroidal androgen receptor modulator with agonist activity on muscle and mixed agonist and antagonist activity on prostate.

NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)

The present invention is directed to novel heterocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

AMIDE DERIVATIVES

Acylanilides of the formula wherein R1 and R2, the same or different, each is cyano, carbamoyl, nitro, halogeno, perfluoroalkyl or other defined substituents; R3 is hydrogen or halogen; R4 is hydrogen or alkyl, or is joined to R5; R5 is hydrogen, hydroxy, alkoxy or acyloxy or is joined to R4; R6 is alkyl or halogenoalkyl, or has the formula ?A-3-R8 or -A4-X2-A5-R9. A1 and A4, the same or different, each is alkylene; A2, A3 and A5, the same or different, each is a direct link or alkylene; X1 and X2, the same or different, each is oxygen, sulphur, sulphinyl, sulphonyl, imino or alkylimino; R7 and R9, the same or different, each is alkyl, alkenyl, hydroxyalkyl, cycloalkyl, phenyl optionally substituted, naphthyl or heterocyclic optionally substituted; and R8 is phenyl, naphthyl or heterocyclic as defined above for R7 or R9; processes for their manufacture and pharmaceutical compositions containing them. The acylanilides possess antiandrogenic activity