21666-68-2

Basic information

• Product Name: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one
• Synonyms: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one;(E)-1-cyclopropyl-3-(diMethylaMino)prop-2-en-1-one;1-Cyclopropyl-3-(diMethylaMino)prop-2-en-1-one;(2Z)-1-cyclopropyl-3-(dimethylamino)prop-2-en-1-one
• CAS NO: 21666-68-2
• Molecular Formula: C₈H₁₃NO
• Molecular Weight: 139.2
• Mol File: 21666-68-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 218.4°C at 760 mmHg
• Flash Point: 76.2°C
• Appearance: /
• Density: 1.031g/cm³
• Vapor Pressure: 0.126mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one(21666-68-2)
• EPA Substance Registry System: 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one(21666-68-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 21666-68-2(Hazardous Substances Data)

Usage

General Description

1-cyclopropyl-3-(dimethylamino)-2-propen-1-one is a chemical compound with a unique molecular structure. It consists of a cyclopropyl ring attached to a propenone group, with a dimethylamino substituent located on the carbon adjacent to the carbonyl group. 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one has potential pharmacological and biological applications due to its diverse structural features. The cyclopropyl ring contributes to its rigidity, while the presence of the dimethylamino group can enhance its solubility and interactions with biological targets. As a result, 1-cyclopropyl-3-(dimethylamino)-2-propen-1-one may be of interest for medicinal and synthetic chemistry research, with potential for use in the development of novel pharmaceuticals or biologically active compounds.

InChI:InChI=1/C8H13NO/c1-9(2)6-5-8(10)7-3-4-7/h5-7H,3-4H2,1-2H3

Upstream product

• 765-43-5 Cyclopropyl methyl ketone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 143621-04-9 (Z)-1-Cyclopropyl-3-[hydroxy-(4-phenoxy-benzyl)-amino]-propenone 
• 143620-94-4 (Z)-3-[(4-Benzyloxy-benzyl)-hydroxy-amino]-1-cyclopropyl-propenone 
• 187163-98-0 6-cyclopropyl-3-nitropyridin-2(1H)-one 
• 1053163-67-9 1-methyl-3-cyclopropylpyrazole 
• 902837-67-6 3-cyclopropyl-1-methyl-1H-pyrazole-4-carbaldehyde 
• 100114-57-6 3-cyclopropyl-1H-pyrazole 
• 957292-12-5 2-(3-cyclopropyl-1H-pyrazol-1-yl)acetic acid 
• 1257637-82-3 3-cyclopropyl-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 101045-94-7 6-Cyclopropyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 1135283-57-6 5-bromo-6-cyclopropyl-2-hydroxynicotinonitrile 
• 1172797-65-7 1-methyl-5-cyclopropyl-pyrazole 

Relevant articles and documents

Selective α-Methylation of Ketones

The convenient and scalable preparative approach for the two-step α-methylation of ketones is described. The optimized protocols for regioselective preparation of enaminones with further diastereoselective and functional groups tolerant hydrogenation to α-methylketones are developed. The scope and limitations of the proposed methodology are discussed. The advantages compared to known procedures are demonstrated. The unexpected role of acetone in the hydrogenation is suggested. The evaluation of the method for both early building block synthesis and late-stage CH-functionalization is shown. The elaborate procedures' preparability and scalability are demonstrated by the synthesis of several α-methyl ketones up to 100 g amount.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds and pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth.

Highly Site-Selective Metal-Free C-H Acyloxylation of Stable Enamines

A highly site-selective acyloxylation of stable enamines with PhI(OAc)2 under metal-free conditions to afford (E)-vinyl acetate derivatives in good to excellent yields is described. Depending on the judicious choice of the solvent system, either the α- or β-site-selective product could be obtained with high selectivity. For the α-site-selective product, the rearranged amide compound is obtained as the major product. This reaction proceeds under mild reaction conditions (room temperature, metal-free, and open-flask) and features a broad substrate scope.