2167-85-3 Usage
Description
Pipazethate is a pyridobenzothiazine derivative with antiarrhythmic characteristics. It is known for its effectiveness as a cough suppressant and is used in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
Pipazethate is used as an antitussive agent for its ability to suppress cough reflexes, providing relief to patients suffering from excessive coughing.
Used in Cardiology:
Pipazethate is used as an antiarrhythmic agent for its potential to regulate abnormal heart rhythms, offering therapeutic benefits to patients with cardiac conditions.
Originator
Theratuss, Squibb ,US ,1962
Manufacturing Process
8.5 parts of 1-azaphenothiazine carboxylic acid chloride and 14 parts of piperidino-ethoxyethanol were introduced into 100 parts of chlorobenzene and the mixture boiled under reflux for 5 minutes. After cooling off the precipitated hydrochloride salt of piperidino-ethoxyethanol was filtered off on a suction filter. Water was added to the filtrate and the pH thereof adjusted to 5 to 6 with dilute HCl. The aqueous phase was then removed, a caustic soda solution added thereto and then extracted with ether. The ethyl extract was washed with water, then dried with potash and the ether distilled off. 9.4 parts of the piperidino-ethoxy-ethyl ester of 1-azaphenothiazine carboxylic acid were obtained. This product was dissolved in 20 parts of isopropanol and the solution neutralized with isopropanolic HCl. The monohydrochloride which precipitated out after recrystallization from isopropanol had a melting point of 160°C to 161°C.
Therapeutic Function
Antitussive
Check Digit Verification of cas no
The CAS Registry Mumber 2167-85-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,6 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2167-85:
(6*2)+(5*1)+(4*6)+(3*7)+(2*8)+(1*5)=83
83 % 10 = 3
So 2167-85-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H25N3O3S/c25-21(27-16-15-26-14-13-23-11-4-1-5-12-23)24-17-7-2-3-8-18(17)28-19-9-6-10-22-20(19)24/h2-3,6-10H,1,4-5,11-16H2
