217090-42-1Relevant articles and documents
Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent
DuMez, Darin,Venkatachalam, Taracad K.,Uckun, Fatih M.
, p. 136 - 151 (2007/10/03)
The arylphosphoramidate derivative of stavudine (STV, d4T, 2',3'-didehydro-3'-deoxythymidine, CAS 3056-17-5), stampidine (STAMP, DDE-113, HI-113, N-[p-(4-bromophenyl)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester, CAS 217178-62-6), is a n
Zidampidine, an aryl phosphate derivative of AZT: In vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus
Uckun,Venkatachalam,Erbeck,Chen,Petkevich,Vassilev
, p. 3279 - 3288 (2007/10/03)
The pharmacokinetics, metabolism, and toxicity of Zidampidine, an aryl phosphate derivative of AZT, 3′-azidothymidine-5′-[p-bromophenyl methoxyalaninyl phosphate] were investigated in CD-1 mice. Following iv injection, Zidampidine was rapidly converted to
Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: Aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07)
D'Cruz, Osmond J.,Uckun, Fatih M.
, p. 317 - 322 (2007/10/03)
aryl phosphate derivative of zidovudine (ZDV), is a potent dual-function contraceptive agent with anti-HIV activity. Its potential for reproductive toxicity was assessed in a series of experiments using CD-1 mice under the conditions of its intended use a