21719-88-0

Basic information

• Product Name: Benzenecarboximidamide, N-(4-fluorophenyl)-
• CAS NO: 21719-88-0
• Molecular Formula: C13H11FN2
• Molecular Weight: 214.242
• Mol File: 21719-88-0.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Benzenecarboximidamide, N-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidamide, N-(4-fluorophenyl)-(21719-88-0)
• EPA Substance Registry System: Benzenecarboximidamide, N-(4-fluorophenyl)-(21719-88-0)

Safety Data

• Hazardous Substances Data: 21719-88-0(Hazardous Substances Data)

Upstream product

• 55-21-0 benzamide 
• 371-40-4 4-fluoroaniline 
• 100-47-0 benzonitrile 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 352-34-1 4-fluoro-1-iodobenzene 
• 1670-14-0 benzamidine monohydrochloride 
• 1765-93-1 4-fluoroboronic acid 
• 618-39-3 benzamidin 

Downstream Products

• 1449576-59-3 2-[1-(4-fluorophenyl)-5-imino-2-phenyl-1H-imidazol-4(5H)-ylidene]malononitrile 
• 1449612-21-8 (Z)-2-{4-[(4-fluorophenyl)imino]-2-phenyl-1H-imidazol-5(4H)-ylidene}malononitrile 
• 1449576-68-4 7-fluoro-2-phenyl-3H-imidazo[4,5-b]quinoline-9-carbonitrile 
• 1449612-12-7 N′-(4-fluorophenyl)-N-(1,2,2-tricyanovinyl)benzamidine 
• 1198463-97-6 (5-fluoro-2-phenyl-1H-indol-3-yl)(phenyl)methanone 
• 89060-64-0 1,5-diphenyl-3-methoxycarbonal-1,2,4-triazole 
• 74669-09-3 methyl α-aminoglyoxylate phenylhydrazone 
• 74669-00-4 3-(4-Fluoro-phenyl)-2-phenyl-5-(phenyl-hydrazono)-3,5-dihydro-imidazol-4-one 
• 371-40-4 4-fluoroaniline 
• 1372776-96-9 N-(4-fluorophenyl)isoquinolin-1-amine 

Relevant articles and documents

Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites

A selective mono-N-arylation strategy of amidines under Chan-Lam conditions is described. During the reaction optimization phase, the isolation of a mononuclear Cu(II) complex provided unique mechanistic insight into the operation of Chan-Lam mono-N-arylation. The scope of the process is demonstrated, and then applied to access the first mono-N-arylated analogues of pentamidine. Sub-micromolar activity against kinetoplastid parasites was observed for several analogues with no cross-resistance in pentamidine and diminazene-resistant trypanosome strains and against Leishmania mexicana. A fluorescent mono-N-arylated pentamidine analogue revealed rapid cellular uptake, accumulating in parasite nuclei and the kinetoplasts. The DNA binding capability of the mono-N-arylated pentamidine series was confirmed by UV-melt measurements using AT-rich DNA. This work highlights the potential to use Chan-Lam mono-N-arylation to develop therapeutic leads against diamidine-resistant trypanosomiasis and leishmaniasis.

Synthesis of 1,2-dihydro-1,3,5-triazine derivativesviaCu(ii)-catalyzed C(sp3)-H activation ofN,N-dimethylethanolamine with amidines

1,2-Dihydro-1,3,5-triazines and symmetrical 1,3,5-triazines were obtained in up to 81% yields from amidines andN,N-dimethylethanolamine catalyzed by CuCl2. The reaction involves three C-N bond formations during the oxidative annulation process

Acid-catalyzed synthesis of imidazole derivatives via N-phenylbenzimidamides and sulfoxonium ylides cyclization

A straightforward method to synthesize imidazole derivatives from amidines and sulfoxonium ylides catalyzed by acids is reported in this study. Specifically, catalyzed by trifluoroacetic acid in DCE solvents can improve synthesis efficiency under metal-fr