217312-98-6Relevant articles and documents
Synthesis of 1-hydroxypyrazole glycine derivatives
Calí, Patrizia,Begtrup, Mikael
, p. 1595 - 1605 (2007/10/03)
A series of novel α-amino acids containing the 1-hydroxypyrazole ring has been prepared by addition of organomagnesium or organolithium intermediates to diethyl N-Boc-iminomalonate as an electrophilic glycine equivalent. Electrophiles, aryl and heteroaryl
Preparation of 5-acyl- and 5-aryl-substituted 1-(benzyloxy)pyrazoles via directed ortho-lithiation/transmetalation and palladium catalyzed cross- coupling
Kristensen, Jesper,Begtrup, Mikael,Vedso, Per
, p. 1604 - 1608 (2007/10/03)
Palladium(0) catalyzed cross-coupling of 1-(benzyloxy)pyrazol-5-ylzinc halides 3a,b, prepared by transmetalation of 1-(benzyloxy)-5-lithiopyrazole (2), with acyl chlorides produced 5 acyl-1-(benzyloxy)pyrazoles 4a-d in high yields. Similar coupling of the