21759-69-3

Basic information

• Product Name: β-N-Methylaminocrotonic acid methyl ester
• Synonyms: β-N-Methylaminocrotonic acid methyl ester
• CAS NO: 21759-69-3
• Molecular Weight: 129.159
• Mol File: 21759-69-3.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 187.5±23.0 °C(Predicted)
• Density: 0.969±0.06 g/cm3(Predicted)
• CAS DataBase Reference: β-N-Methylaminocrotonic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: β-N-Methylaminocrotonic acid methyl ester(21759-69-3)
• EPA Substance Registry System: β-N-Methylaminocrotonic acid methyl ester(21759-69-3)

Safety Data

• Hazardous Substances Data: 21759-69-3(Hazardous Substances Data)

Upstream product

• 4091-39-8 3-chloro-2-butanone 
• 105-45-3 acetoacetic acid methyl ester 
• 74-89-5 methylamine 
• 624-90-8 methyl azide 
• 623-43-8 methyl crotonate 
• 17041-60-0 dimethyl ethylidenemalonate 
• 622-29-7 N-Benzylidenemethylamine 
• 41607-86-7 β-Azidoisovaleriansaeuremethylester 

Downstream Products

• 133765-28-3 4-(4-Chloro-phenyl)-2,3-dimethyl-3,4-dihydro-chromeno[3,4-b]pyrrole-1-carboxylic acid methyl ester 
• 133765-31-8 (Z)-2-[2-(4-Chloro-phenyl)-3-nitro-chroman-4-yl]-3-methylamino-but-2-enoic acid methyl ester 
• 82140-48-5 3-Methylamino-2-(3-trifluoromethylbenzoyl)-2-butensaeure-methylester 
• 68870-58-6 methyl 3-(p-chlorophenyl)-5-methylisoxazole-4-carboxylate 
• 1423699-80-2 C₁₃H₁₄BrNO₃ 
• 1423700-51-9 C₁₈H₂₅BrN₂O₃Si 
• 1423700-49-5 methyl 3-(4-bromophenyl)-5-methyl-1H-pyrazole-4-carboxylate 
• 90145-26-9 1,5-dimethyl-3-phenyl-1H-pyrazole-4-carboxylic acid methylester 
• 1393485-92-1 methyl 3-(4-fluorophenyl)-1,5-dimethyl-1H-pyrazole-4-carboxylate 
• 1391908-11-4 methyl 3-methyl-5-(4-nitrophenyl)isoxazole-4-carboxylate 
• 85963-91-3 methyl 2-(4-nitrobenzoyl)-3-oxobutanoate 
• 1361018-99-6 methyl 5-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-carboxylate 

Relevant articles and documents

Synthesis of Spiro-Δ2-Pyrrolin-4-One Pseudo Enantiomers via an Organocatalyzed Sulfa-Michael/Aldol Domino Sequence

Δ2-Pyrrolin-4-ones undergo organocatalyzed sulfa-Michael/aldol domino spirocyclizations with mercaptoacetaldehyde dimer. The products contain three contiguous stereocenters (ee up to 99%, dr up to 95:5, 25 examples) and can be transformed into analogues of natural products. With the use of a single catalyst, the absolute configuration of the products were determined by the configuration of the exocyclic double bond of the starting material. These results point at the possibility of a widespread use of unsaturated Δ2-pyrrolin-4-ones in various (organo)catalyzed (cascade) transformations for accessing libraries of 3D-rich pyrrolone-based (spiro)heterocycles. (Figure presented.).

Isoquinolin-1(2H)-ones and 1,6-naphthyridin-5(6H)-ones by an N-acylation-SNAr sequence

A new synthesis of 2,3-dialkyl-4-carbomethoxyisoquinolin-1(2H)-ones and 6,7-dialkyl-8-carbomethoxy-1,6-naphthyridin-5(6H)-ones is reported. The process involves treatment of a β-enaminoester with 2-fluoro-5-nitrobenzoyl chloride, 2-fluorobenzoyl chloride or 2-chloronicotinoyl chloride followed by heating in the presence of base. The conversion, which proceeds by an N-acylation-SNAr reaction sequence, affords 50-86% yields when R 1 is n-alkyl but ≤30% yields when R1 is α-branched.

LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.