2176-63-8

Basic information

• Product Name: 2,3,5,6-TETRACHLOROPYRIDIN-4-AMINE
• Synonyms: 2,3,5,6-TETRACHLOROPYRIDIN-4-AMINE;4-Pyridinamine, 2,3,5,6-tetrachloro-;4-Amino-2,3,5,6-tetrachloropyridine;tetrachloropyridin-4-aMine;2,3,5,6-Tetrachloro-4-aMinopyridine
• CAS NO: 2176-63-8
• Molecular Formula: C₅H₂Cl₄N₂
• Molecular Weight: 231.89
• EINECS: -0
• Mol File: 2176-63-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 212 °C
• Boiling Point: 333.8°Cat760mmHg
• Flash Point: 155.7°C
• Appearance: /
• Density: 1.746g/cm³
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: 2-8°C
• PKA: -3.41±0.50(Predicted)
• CAS DataBase Reference: 2,3,5,6-TETRACHLOROPYRIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-TETRACHLOROPYRIDIN-4-AMINE(2176-63-8)
• EPA Substance Registry System: 2,3,5,6-TETRACHLOROPYRIDIN-4-AMINE(2176-63-8)

Safety Data

• Hazardous Substances Data: 2176-63-8(Hazardous Substances Data)

Usage

General Description

2,3,5,6-Tetrachloropyridin-4-amine is a chemical compound with the molecular formula C5HCl4N. It is a derivative of pyridine and contains four chlorine atoms. 2,3,5,6-TETRACHLOROPYRIDIN-4-AMINE is used primarily as a building block in the synthesis of pesticides, pharmaceuticals, and other organic compounds. It is also known to have potential applications in the field of material science due to its unique chemical properties. However, 2,3,5,6-Tetrachloropyridin-4-amine is considered to be a hazardous substance and should be handled and stored with caution to prevent harm to human health and the environment.

InChI:InChI=1/C5H2Cl4N2/c6-1-3(10)2(7)5(9)11-4(1)8/h(H2,10,11)

Upstream product

• 17325-31-4 2,6-Dihydroxy-4-amino-pyridin 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 28443-69-8 4-amino-2,3,5-trichloropyridine 
• 50524-37-3 4-amino-3,5,6-trichloro-pyridin-2-ol 
• 10026-13-8 phosphorus pentachloride 
• 7664-41-7 ammonia 
• 10025-87-3 trichlorophosphate 
• 107-10-8 propylamine 
• 75-31-0 isopropylamine 
• 2808-86-8 2,3,4,5-tetrachloro-pyridine 
• 87052-66-2 2,3,5,6-Tetrachloro-4-pyridylcarbonimidoyl Dichloride 

Downstream Products

• 87052-69-5 N,N'-Diphenyl-N''-(2,3,5,6-tetrachloro-pyridin-4-yl)-guanidine 

Relevant articles and documents

Reactions of 4-(dimethylamino)pyridinium activated pentachloropyridine with nitrogen nucleophiles and hydride

Substitution reactions on 2′,3′,5′,6′-tetrachloro-4-dimethylamino-[1,4]bipyridinyl-1-ylium chloride with nitrogen nucleophiles such as n-propylamine, isopropylamine, glycine, morpholine, and piperidine were examined. Highly functionalized Cl2,Cl3,N4,Cl5,Cl6- and N2,Cl3,N4,Cl5,Cl6-substituted pyridines were obtained, in part possessing unsubstituted 4-amino groups due to dealkylation. Detailed NMR studies were performed in order to elucidate the regiochemistry of these dealkylations.

MECHANISM FOR REACTIONS OF HALOGENATED COMPOUNDS. PART 4. ACTIVATING INFLUENCES OF RING-NITROGEN AND TRIFLUOROMETHYL IN NUCLEOPHILIC AROMATIC SUBSTITUTION

Rate constants have been measured for the reactions of ammonia with various fluorinated pyridines and diazines in aqueous dioxan at 25 deg C.From the results the activating effects of ring-nitrogen (relative to C-H) and of trifluoromethyl (relative to -H)