21771-88-0

Basic information

• Product Name: 2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID
• Synonyms: 2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID
• CAS NO: 21771-88-0
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.69
• Mol File: 21771-88-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 116-117 °C(Solv: benzene (71-43-2))
• Boiling Point: 379 °C at 760 mmHg
• Flash Point: 183 °C
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 2.02E-06mmHg at 25°C
• Refractive Index: 1.608
• PKA: 4.62±0.10(Predicted)
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID(21771-88-0)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID(21771-88-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 21771-88-0(Hazardous Substances Data)

Usage

Description

2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID, also known as fenoprofen, is a nonsteroidal anti-inflammatory drug (NSAID) characterized by its ability to relieve pain and reduce inflammation. It functions by inhibiting the production of prostaglandins, which are chemicals responsible for causing pain and inflammation in the body.
Used in Pharmaceutical Industry:
2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID is used as an analgesic and anti-inflammatory agent for the treatment of conditions such as arthritis. It is effective in managing mild to moderate pain and is available both as a prescription and over-the-counter medication.
However, it is not recommended for long-term use due to the potential for serious side effects, including gastrointestinal bleeding and kidney damage. Therefore, it is crucial to use 2-(4-CHLOROPHENYL)-2-PHENYLACETIC ACID under the guidance of a healthcare professional and to adhere to the prescribed dosage and duration of treatment to minimize the risk of adverse effects.

InChI:InChI=1/C14H11ClO2/c15-12-8-6-11(7-9-12)13(14(16)17)10-4-2-1-3-5-10/h1-9,13H,(H,16,17)

Upstream product

• 4578-80-7 2-(p-Chlorophenyl)-2-phenylacetonitrile 
• 5468-17-7 (+/-)-erythro-3-phenyl-2-(4-chloro-phenyl)-succinic acid diamide 
• 53370-25-5 1-(p-Chlorphenyl)-1-phenyl-N,N-dimethyl-methylamin 
• 124-38-9 carbon dioxide 
• 55816-27-8 4-chlorobenzophenone hydrazone 
• 106-39-8 bromochlorobenzene 
• 103-82-2 phenylacetic acid 
• 134-85-0 4-chlorobenzophenone 
• 53780-26-0 2-(4-chlorophenyl)-2-phenyloxirane 
• 140-53-4 p-chlorobenzyl cyanide 
• 71-43-2 benzene 
• 53731-99-0 2-bromo-2-(4-chlorophenyl)acetonitrile 
• 201230-82-2 carbon monoxide 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 

Downstream Products

• 33142-34-6 (4-chloro-phenyl)-phenyl-acetic acid anilide 
• 88875-62-1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester 
• 71491-88-8 2-(4-chlorophenyl)-2-phenylacetyl chloride 
• 129315-96-4 2-(4-chlorophenyl)-2-phenyl-4-pentenoic acid 
• 134-85-0 4-chlorobenzophenone 
• 88875-70-1 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 
• 129315-93-1 2-(4-chlorophenyl)-2-phenylcyclopent-4-enone 
• 129315-76-0 2-(4-chlorophenyl)-2-phenylcyclopentanone 
• 129315-83-9 cis-(1R^*,2R^*)-2-(4-chlorophenyl)-2-phenylcyclopentanol 
• 129315-83-9 trans-(1S^*,2R^*)-2-(4-chlorophenyl)-2-phenylcyclopentanol 
• 1061757-59-2 C₂₉H₂₆ClNO 
• 1061757-73-0 C₂₃H₂₂ClNO 
• 3691-35-8 chlorophacinone 

Relevant articles and documents

An Alternative and efficient route to chlorophacinone

A straightforward synthesis for the anticoagulant rodenticide chlorophacinone is described. The short synthesis uses commercially available mandelic acid and 1,3-indanedione as staring materials.

Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2

The first ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2 to generate important aryl acetic acids is reported. Besides aldehyde hydrazones, a variety of ketone hydrazones, which have not been successfully applied in previous umpolung reactions with other reactive electrophiles, also show high reactivity and selectivity under mild conditions. Moreover, this operationally simple protocol features good functional group tolerance, is readily scalable, and offers easy derivation of important structures, including bioactive felbinac and adiphenine. Computational studies reveal that this umpolung reaction proceeds through the generation of a Ru-nitrenoid followed by concerted [4 + 2] cycloaddition with CO2.

Diastereoselectivity in the reduction of sterically unbiased 2,2-diarylcyclopentanones

Reduction of sterically unbiased 2-phenyl-2-(4-X-phenyl)cyclopentanones 1 (X = NO2, Br, Cl, OCH3, OH, NH2) with either sodium borohydride in methanol or lithium borohydride in tetrahydrofuran at 0°C produced diastereomeric