21803-90-7

Basic information

• Product Name: N-(2-(1H-indol-3-yl)ethyl)-3-phenylpropanamide
• Synonyms: N-(2-(1H-indol-3-yl)ethyl)-3-phenylpropanamide
• CAS NO: 21803-90-7
• Molecular Weight: 292.381
• Mol File: 21803-90-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-(2-(1H-indol-3-yl)ethyl)-3-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(1H-indol-3-yl)ethyl)-3-phenylpropanamide(21803-90-7)
• EPA Substance Registry System: N-(2-(1H-indol-3-yl)ethyl)-3-phenylpropanamide(21803-90-7)

Safety Data

• Hazardous Substances Data: 21803-90-7(Hazardous Substances Data)

Upstream product

• 61-54-1 tryptamine 
• 501-52-0 3-Phenylpropionic acid 
• 54519-07-2 vinyl ester of 3-phenylpropionic acid 
• 710-11-2 2-oxo-4-phenylbutyric acid 
• 122-97-4 3-Phenyl-1-propanol 
• 63677-96-3 (E)-2-hydroxy-2-methyl-5-phenylpent-4-en-3-one 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 1021870-25-6 C₁₉H₁₈N₂O₂ 
• 110359-08-5 1-(2-phenylethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 
• 102883-35-2 1-phenethyl-4,9-dihydro-3H-β-carboline 

Relevant articles and documents

Multi-gram preparation of cinnamoyl tryptamines as skin whitening agents through a chemo-enzymatic flow process

A 2-step flow-based chemo-enzymatic synthesis of selected cinnamoyl tryptamines as potential cosmetic ingredients has been developed. A first reaction catalyzed by immobilized Pd(OAc)2 gave the acyl donors employed as starting material in the s

METHOD FOR SYNTHESISING AMIDES

The present invention relates to a method for synthesising amides that is of general applicability. The method may be performed in vitro or in vivo. Cell lines for use in the in vivo methods also form aspects of the invention. The method for synthesising a non-natural amide comprises: a. reaction of a carboxylic acid with a naturally occurring CoA ligase or a variant thereof; and b. reaction of the product of step a with an amine in the presence of a naturally occurring acyltransferase or a variant thereof; with the proviso that where the CoA ligase and acyltransferase are both naturally occurring, they are not derived from the same source species and do not act sequentially in a metabolic pathway; and with the proviso that the non-natural product is not N-(E)-p-coumaroyl-3-hydroxyanthranilic acid or N-(E)-p-caffeoyl-3-hydroxyanthranilic acid. Further, a method for producing an active pharmaceutical ingredient by the aforementioned method and host cells for carrying out said methods are envisaged.

Catalytic amide formation with α′-hydroxyenones as acylating reagents

α′-Hydroxyenones undergo clean, catalytic amidations with amines promoted by the combination of an N-heterocyclic carbene and 1,2,4-triazole. The Royal Society of Chemistry 2009.