218152-30-8

Basic information

• Product Name: Acetamide, N-[6-[2-(4-nitrophenyl)ethoxy]-1H-purin-2-yl]-
• CAS NO: 218152-30-8
• Molecular Formula: C15H14N6O4
• Molecular Weight: 342.314
• Mol File: 218152-30-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[6-[2-(4-nitrophenyl)ethoxy]-1H-purin-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[6-[2-(4-nitrophenyl)ethoxy]-1H-purin-2-yl]-(218152-30-8)
• EPA Substance Registry System: Acetamide, N-[6-[2-(4-nitrophenyl)ethoxy]-1H-purin-2-yl]-(218152-30-8)

Safety Data

• Hazardous Substances Data: 218152-30-8(Hazardous Substances Data)

Upstream product

• 100-27-6 2-(4-nitrophenyl)ethanol 
• 3056-33-5 2,9-diacetylguanine 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 917376-69-3 N²,N⁹-diacetyl-O⁶-2-(4-nitrophenyl)ethylguanine 

Downstream Products

• 316353-09-0 (2S,4S)-3-benzyloxycarbonyl-2-tert-butyl-4-(3-{N²-acetyl-O⁶-[2-(4-nitrophenyl)ethyl]-9-guaninyl}propyl)oxazolidin-5-one 
• 917376-87-5 O⁶-[2-(4-nitrophenyl)ethyl]-N²-[2-(4-nitrophenyl)ethoxycarbonyl]-9-{5-O-(4,4'-dimethoxytrityl)-2-O-[2-(4-nitrophenyl)ethoxycarbonyl]-α-D-arabinofuranosyl}guanine 
• 917376-86-4 O⁶-[2-(4-nitrophenyl)ethyl]-N²-[2-(4-nitrophenyl)ethoxycarbonyl]-9-{5-O-(4-monomethoxytrityl)-2-O-[2-(4-nitrophenyl)ethoxycarbonyl]-α-D-arabinofuranosyl}guanine 
• 917474-26-1 O⁶-[2-(4-nitrophenyl)ethyl]-N²-[2-(4-nitrophenyl)ethoxycarbonyl]-9-{3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-[2-(4-nitrophenyl)ethoxycarbonyl]-α-D-arabinofuranosyl}guanine 
• 917376-75-1 O⁶-[2-(4-nitrophenyl)ethyl]-N²-[2-(4-nitrophenyl)ethoxycarbonyl]-9-(2,3,5-tri-O-benzoyl-α-D-arabinofuranosyl)guanine 
• 917376-79-5 O⁶-[2-(4-nitrophenyl)ethyl]-N²-[2-(4-nitrophenyl)ethoxycarbonyl]-9-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-α-D-arabinofuranosyl]guanine 
• 917376-84-2 O⁶-[2-(4-nitrophenyl)ethyl]-N²-[2-(4-nitrophenyl)ethoxycarbonyl]-9-{2-O-[2-(4-nitrophenyl)ethoxycarbonyl]-α-D-arabinofuranosyl}guanine 
• 917376-74-0 O⁶-[2-(4-nitrophenyl)ethyl]-9-(2,3,5-tri-O-benzoyl-α-D-arabinofuranosyl)guanine 
• 917376-76-2 O⁶-[2-(4-nitrophenyl)ethyl]-N²-[2-(4-nitrophenyl)ethoxycarbonyl]-9-(α-D-arabinofuranosyl)guanine 
• 917376-77-3 O⁶-[2-(4-nitrophenyl)ethyl]-9-[3,5-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-α-D-arabinofuranosyl]guanine 
• 917376-72-8 O⁶-[2-(4-nitrophenyl)ethyl]-9-(α-D-arabinofuranosyl)guanine 

Relevant articles and documents

N2-acetyl-O6-(2-(p-nitrophenyl)ethyl)guanine: A convenient building block for the synthesis of 9-substituted guanine derivatives

Readily accessible N2-acetyl-O6-(2-(p-nitrophenyl)ethyl)guanine can undergo Mitsunobu reactions with either a primary or secondary alcohol to generate guanine derivatives. X-ray data indicates that only the desired 9- subsituted derivatives of guanine are formed.

Synthesis of N-Boc and N-Fmoc dipeptoids with nucleobase residues as peptoid nucleic acid monomers

The synthesis of Boc and Fmoc protected peptoid nucleic acid monomers bearing thymine (4a, 4b), adenine (6a, 6b) or guanine (7a, 7b) on the side chain is described. These nucleobases were attached to the amino group of glycine via an ethylene linkage using the Mitsunobu reaction, except cytosine, which was attached using alkylation. After deprotection, these amino acids have been used for synthesizing N-Boc and N-Fmoc dipeptoids.