21816-07-9Relevant articles and documents
ADAMANTANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION
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Paragraph 1045-1047, (2020/02/05)
Compounds of structural Formula I were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus, wherein, R1, R2, R3, X and Y are defined in the specification.
Electronic Control of Face Selection in the Capture of Radicals
Bodepudi, Vani R.,Noble, William J. le
, p. 2001 - 2006 (2007/10/02)
A simple procedure is described which leads to the pure epimeric 2-(5-phenyl)adamantanecarboxylic acids E-1 and Z-1.Both acids upon treatment with bromine and mercuric oxide in carbon tetrachloride undergo the Hunsdiecker reaction to give the same mixture of E- and Z-2-bromo-5-phenyladamantanes 4. 5-Phenyl-2-methyleneadamantane 6 undergoes reaction with bromotrichloromethane to give two diastereomeric adducts.In both instances, the major isomer results from the abstraction of a bromine atom by the zu face of the intermediate 5-phenyl-2-adamantyl radicals.The results mesh with other examples of face selection which have previously ascribe d to transitions state hyperconjugation.In additional case (hydride shift in a carbocation) was encountered in this work, as well as one apparent exception: the oxirane formation from adamantanone and sulfonium ylids.That result is attributed to thermodynamic control of the initial addition step.
