21855-43-6

Basic information

• Product Name: 2-Cyclohexene-1-carboxylic acid, 2-hydroxy-6-methyl-4-oxo-, ethyl ester
• CAS NO: 21855-43-6
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Mol File: 21855-43-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Cyclohexene-1-carboxylic acid, 2-hydroxy-6-methyl-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclohexene-1-carboxylic acid, 2-hydroxy-6-methyl-4-oxo-, ethyl ester(21855-43-6)
• EPA Substance Registry System: 2-Cyclohexene-1-carboxylic acid, 2-hydroxy-6-methyl-4-oxo-, ethyl ester(21855-43-6)

Safety Data

• Hazardous Substances Data: 21855-43-6(Hazardous Substances Data)

Upstream product

• 10544-63-5 ethyl crotonate 
• 141-97-9 ethyl acetoacetate 
• 625-33-2 3-penten-2-one 
• 105-53-3 diethyl malonate 

Downstream Products

• 21855-46-9 ethyl 3,5-dibromo-2,4-dihydroxy-6-methyl benzoate 
• 2524-37-0 ethyl orselinate 

Relevant articles and documents

Zearalenone mimics: Synthesis of (E)-6-(1-Alkenyl)-substituted β-resorcylic acid esters

Two versatile strategies for the synthesis of mimics of the Fusarium mycotoxin zearalenone (1) have been developed. Optimized preparation of (E)-6-(1-alkenyl) substituted β-resorcylic acid esters was realized via ortho-directed lithiation of variable substrates combined with allylation/isomerization or via formylation/Schlosser-Wittig olefination using different protective group patterns. Spontaneous decarboxylation of (E)-6-(1-alkenyl) substituted β-resorcylic acids indicated the influence of this substituent on the chemical behavior of these compounds. These mimics were already used for the development of optimized standard protocols for the synthesis of phase II metabolites of ZEN (glucosides, glucuronides), and further applications (i.e., sulfate conjugates) are still under investigation. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.