21892-60-4

Basic information

• Product Name: 1-(4-BROMOPHENYL)-2-NITROPROPENE
• Synonyms: 1-bromo-4-(2-nitro-1-propen-1-yl)benzene
• CAS NO: 21892-60-4
• Molecular Formula: C₉H₈BrNO₂
• Molecular Weight: 242.07
• Product Categories: Propanes/propenes
• Mol File: 21892-60-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-BROMOPHENYL)-2-NITROPROPENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)-2-NITROPROPENE(21892-60-4)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)-2-NITROPROPENE(21892-60-4)

Safety Data

• Hazardous Substances Data: 21892-60-4(Hazardous Substances Data)

Usage

Description

1-(4-BROMOPHENYL)-2-NITROPROPENE, with the molecular formula C9H8BrNO2, is a nitroalkene chemical compound characterized by the presence of a nitro group and a carbon-carbon double bond. It is a yellow solid at room temperature and is insoluble in water. Due to its potential hazardous properties, it should be handled with care and used in a controlled laboratory environment.

Uses

Used in Pharmaceutical Synthesis:
1-(4-BROMOPHENYL)-2-NITROPROPENE is used as an intermediate in the synthesis of various organic molecules, particularly in the pharmaceutical industry. Its unique structure allows for the creation of biologically active compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Production:
In the agrochemical industry, 1-(4-BROMOPHENYL)-2-NITROPROPENE is utilized as a key component in the synthesis of various agrochemicals. Its role as an intermediate aids in the production of compounds that can be used in the development of pesticides, herbicides, and other agricultural chemicals to improve crop yield and protect against pests.

Upstream product

• 79-24-3 Nitroethane 
• 1122-91-4 4-bromo-benzaldehyde 
• 135711-48-7 [1-(4-Bromo-phenyl)-2-nitro-propyl]-butyl-amine 
• 75-52-5 nitromethane 
• 631-61-8 ammonium acetate 
• 64-18-6 formic acid 
• 141-43-5 ethanolamine 

Downstream Products

• 6186-22-7 4-bromophenyl acetone 
• 13235-83-1 (±)-1-(4-bromophenyl)propan-2-amine 
• 103675-99-6 p-bromophenylacetone oxime 
• 93564-56-8 N-hydroxy-p-bromoamphetamine 
• 13213-36-0 1-phenylpropan-2-one oxime 
• 104736-34-7 (Z)-1-(4-bromophenyl)-2-propanone oxime 
• 104749-39-5 (E)-1-(4-bromophenyl)-2-propanone oxime 
• 1215288-74-6 1-acetylamino-2-bromo-1-(4-bromophenyl)-2-nitropropane 
• 1306633-96-4 5-(4-bromophenyl)-4-methyl-2-phenylthiazole 
• 1306633-99-7 5-(4-bromophenyl)-2-(4-methoxyphenyl)-4-methylthiazole 
• 1442645-54-6 C₂₀H₁₈BrNO₂ 
• 17492-65-8 2-(4-bromophenyl)-3-methylquinoxaline 
• 1441127-82-7 C₁₅H₁₃BrO₂ 
• 1453201-21-2 (R)-1-bromo-4-(2-nitropropyl)benzene 

Relevant articles and documents

Protein arginine methyltransferase 5 (PRMT5) inhibitor, pharmaceutical products thereof, and methods thereof

The present invention provides a PRMT5 inhibitor of formula (I); R1 is a non-hydrogen monovalent group; W is a direct bond or-NH-; T, U and V are independently from each other selected from C and N; R2 is H or halogen; m is 1 or 2; X is carbon, nitrogen or oxygen; Y is C or N; Z is a direct bond or carbon; R3 is H, a non-hydrogen monovalent group, an oxo group, a divalent spiro-forming group or adivalent bridge-forming group; and n is 1 or 2, and represents a single or double bond. The present invention also provides pharmaceutical products comprising the PRMT5 inhibitor and use thereof in the treatment of proliferative disorders such as cancer, metabolic disorders, hematological disorders, autoimmune diseases and inflammatory diseases.

A diversity-oriented synthesis of polyheterocycles: Via the cyclocondensation of azomethine imine

Pd-Catalyzed sequential reactions to afford skeletally diverse molecules are described. The reaction involved azomethine imine formation and a cyclocondensation reaction as individual steps. The methodology provides excellent regio- and stereocontrol. Skeletal diversity was ensured by changing the electrophilic counterpart of azomethine imine. Due to its broader diversity and complexity, the DOS methodology is likely to benefit drug discovery and development in the future.

PROCESS FOR THE PREPARATION OF LACTAMS FROM GLYOXYLIC ACID

A process for the synthesis of lactams suitable for use in antimicrobial, anti-biofilm bacteriostatic compositions.