21900-56-1

Basic information

• Product Name: Benzoyl chloride, 2-chloro-3-methyl-
• CAS NO: 21900-56-1
• Molecular Formula: C8H6Cl2O
• Molecular Weight: 189.041
• Mol File: 21900-56-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 2-chloro-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-chloro-3-methyl-(21900-56-1)
• EPA Substance Registry System: Benzoyl chloride, 2-chloro-3-methyl-(21900-56-1)

Safety Data

• Hazardous Substances Data: 21900-56-1(Hazardous Substances Data)

Upstream product

• 15068-35-6 2-chloro-3-methylbenzoic acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 99520-00-0 3-(4-chlorobenzoyl)-4-chlorotoluene 
• 813447-26-6 C₂₁H₃₁ClN₂O₃ 
• 1422389-77-2 C₁₄H₁₀ClFN₂O₃ 
• 1115276-77-1 N-benzyl-2-chloro-3-methylbenzamide 
• 99533-74-1 5-amino-1-(3-[4-chlorobenzoyl]-4-chlorobenzyl)-1,2,3-triazole-4-carboxamide 
• 99520-02-2 3-(4-chlorobenzoyl)-4-chlorobenzyl azide 
• 99520-01-1 3-(4-chlorobenzoyl)-4-chlorobenzyl bromide 

Relevant articles and documents

Synthesis of ArCF2X and [18F]Ar-CF3via Cleavage of the Trifluoromethylsulfonyl Group

A versatile synthesis of ArCF2X and [18F]Ar-CF3 type compounds from readily available ArCF2SO2CF3 has been developed. Diverse nucleophiles, including weak nucleophiles such as halides (18F-, Cl-, Br-, and I-), RSH, and ROH, could react with ArCF2SO2CF3 efficiently to give the corresponding difluoromethylene products. The control experiments and the Hammett plot indicated that the reaction might proceed through a difluorocarbocation intermediate generated from the steric hindrance-assisted cleavage of the trifluoromethylsulfonyl group.

Palladium-catalyzed intramolecular C-H arylation of 2-halo-: N -Boc- N -arylbenzamides for the synthesis of N-H phenanthridinones

A palladium catalyzed synthesis of N-H phenanthridinones was developed via C-H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for the less reactive o-chlorobenzamides.

Palladium-catalyzed annulation of haloanilines and halobenzamides using norbornadiene as an acetylene synthon: A route to functionalized indolines, isoquinolinones, and indoles

A general procedure for the palladium-catalyzed annulation of substituted haloanilines with norbornadiene gives functionalized indolines in 51-98% yield. These indolines can be rapidly converted to benzenoid- substituted indoles and tricyclic indolines. Extension to the use of substituted halobenzamides gives functionalized isoquinolinones in up to 86% yield.