21900-62-9

Basic information

• Product Name: Benzoyl chloride, 4-(1-methylethyl)- (9CI)
• Synonyms: Benzoyl chloride, 4-(1-methylethyl)- (9CI);4-(1-Methylethyl)benzoyl chloride
• CAS NO: 21900-62-9
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.64674
• Product Categories: ACIDHALIDE
• Mol File: 21900-62-9.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 121 °C(Press: 10 Torr)
• Appearance: Pale yellow/Liquid
• Density: 1.100±0.06 g/cm3(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: Benzoyl chloride, 4-(1-methylethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 4-(1-methylethyl)- (9CI)(21900-62-9)
• EPA Substance Registry System: Benzoyl chloride, 4-(1-methylethyl)- (9CI)(21900-62-9)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 21900-62-9(Hazardous Substances Data)

Upstream product

• 536-66-3 p-isopropylbenzoic acid 
• 17356-09-1 4-iodocumene 
• 141-75-3 butyryl chloride 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 67032-14-8 1-(4-isopropyl-benzoyloxy)-3-(2-methyl-piperidino)-propane; hydrochloride 
• 20185-55-1 p-isopropylbenzoic acid methyl ester 
• 4380-73-8 4-isopropyl-benzoic acid sulfanilylamide 
• 36816-95-2 (E)-3-(4-Isopropyl-benzoylamino)-2-methyl-but-2-enoic acid ethyl ester 
• 36816-99-6 (E)-2-Ethyl-3-(4-isopropyl-benzoylamino)-but-2-enoic acid ethyl ester 
• 22261-56-9 2-(4-isopropyl-phenyl)-3-methyl-benzothiazolium; iodide 
• 104277-50-1 2-(4-Isopropyl-benzoylamino)-pentanedioic acid 
• 166765-50-0 4,4-dimethyl-2-(4-isopropylphenyl)oxazoline 
• 250234-21-0 2-[4-benzyl-8-(4-isopropylbenzoyl)-3-oxo-1-thia-4,8-diazaspiro[4.5]-decan-2-yl]-acetic acid 
• 1198591-84-2 3-(3-furanyl)-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-1H-indole-6-carboxylic acid 
• 1198592-87-8 methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-[2-(methyloxy)phenyl]-1H-indole-6-carboxylate 

Relevant articles and documents

Rh(iii)-Catalyzed three-component cascade annulation to produce theN-oxopropyl chain of isoquinolone derivatives

Developing powerful methods to introduce versatile functional groups at theN-substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct theN-oxopropyl chain of isoquinolone derivativesviarhodium(iii)-catalyzed C-H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.

Pyrrolopyrimidine BTK inhibitor as well as preparation method and application thereof

The invention provides a pyrrolopyrimidine BTK inhibitor as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound has the structural general formula shown in a formula (I). In-flight

Essential oil-based design and development of novel anti-Candida azoles formulation

Candida is the most common fungal class, causing both superficial and invasive diseases in humans. Although Candida albicans is the most common cause of fungal infections in humans, C. auris is a new emergent serious pathogen causing complications similar to those of C. albicans. Both C. albicans and C. auris are associated with high mortality rates, mainly because of their multidrug-resistance patterns against most available antifungal drugs. Although several compounds were designed against C. albicans, very few or none were tested on C. auris. Therefore, it is urgent to develop novel effective antifungal drugs that can accommodate not only C. albicans, but also other Candida spp., particularly newly emergent one, including C. auris. Inspired by the significant broad-spectrum antifungal activities of the essential oil cuminaldehyde and the reported wide incorporation of azoles in the antifungal drugs, a series of compounds (UoST1-11) was designed and developed. The new compounds were designed to overcome the toxicity of the aldehyde group of cuminaldehyde and benefit from the antifungal selectivity of azoles. The new developed UoST compounds showed significant anti-Candida activities against both Candida species. The best candidate compound, UoST5, was further formulated into polymeric nanoparticles (NPs). The new formula, UoST5-NPs, showed similar activities to the nanoparticles-free drug, while providing only 25% release after 24 h, maintainng prolonged activity up to 48 h and affording no toxicity. In conclusion, new azole formulations with significantly enhanced activities against C. albicans and C. auris, while maintaining prolonged action and no toxicities at lower concentrations, were developed.