21905-73-7Relevant articles and documents
Hydrophobicity constants for several xanthones and flavones
Pogodaeva,Medvedeva,Sukhov,Shishmareva
, p. 38 - 42 (2011)
The octanol-water distribution of several xanthones and flavones was studied. Their hydrophobicity constants (log P) were determined. The lipophilicity constants (π) of the substituents were calculated. The relationship between the structure and hydrophobicity constants of the gamma-pyrone derivatives was found.
Formal Aniline Synthesis from Phenols through Deoxygenative N-Centered Radical Substitution
Lardy, Samuel W.,Luong, Kristine C.,Schmidt, Valerie A.
supporting information, p. 15267 - 15271 (2019/12/11)
Phenolic, lignin-derived substrates have emerged as desirable biorenewable chemical feedstocks for coupling reactions. A radical-mediated conversion of phenol derivatives to anilines is reported, using unfunctionalized hydroxamic acids as the N-centered radical source. The applicability of this triethyl phosphite mediated O-atom transfer approach, which tolerates a range of steric and electronic demands to naturally occurring phenols and lignin models, has been demonstrated in this work to access the corresponding aniline derivatives.
Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties
Waszkielewicz, Anna M.,S?oczyńska, Karolina,P?kala, El?bieta,?mudzki, Pawe?,Siwek, Agata,Grybo?, Anna,Marona, Henryk
, p. 339 - 352 (2017/04/03)
A series of new xanthone derivatives have been synthesized and evaluated for their anticonvulsant properties in the maximal electroshock, subcutaneous metrazole tests and for neurotoxicity in the rotarod in mice, i.p. and rats, p.o. Compound 9: R,S-2-{2-[(1-hydroxybutan-2-yl]amino)ethoxy}-9H-xanthen-9-one and compound 12: R,S-2-{3-[(1-hydroxybutan-2-yl)amino]propoxy}-9H-xanthen-9-one exerted activity in rats, p.o. 2 and 4?h after administration, respectively. Therefore, metabolic stability of the compounds was evaluated with use of rat microsomes, resulting in half-life t1/2 136 and 108?min, respectively, indicating that either the metabolites are very active or the parent compounds exert ADME properties other than metabolism which influence the late onset of activity.
