21906-39-8 Usage
Description
3-(Trifluoromethyl)phenylacetone, also known as 3-(CF3)C6H4COCH3, is an organic compound characterized by the presence of a trifluoromethyl group attached to a phenyl ring, with an acetone functional group attached to the same phenyl ring. It is a clear yellow liquid and is commonly utilized in the synthesis of various chemical compounds.
Uses
Used in Pharmaceutical Industry:
3-(Trifluoromethyl)phenylacetone is used as a synthetic intermediate for the production of various pharmaceutical compounds. Its application is primarily due to its ability to undergo reductive amination reactions, which are crucial in the synthesis of specific drug molecules.
Used in Synthesis of (±)-[1-(3-trifluoromethyl)phenyl]-2-propylamine:
3-(Trifluoromethyl)phenylacetone is used as a key reactant in the synthesis of (±)-[1-(3-trifluoromethyl)phenyl]-2-propylamine, a compound with potential applications in the pharmaceutical industry. The reductive amination reaction involving 3-(Trifluoromethyl)phenylacetone allows for the formation of this target molecule.
Used in Synthesis of N-2-[1-methyl-2-(3-trifluoromethylphenyl]-aminoethanol:
3-(Trifluoromethyl)phenylacetone is also utilized in the synthesis of N-2-[1-methyl-2-(3-trifluoromethylphenyl]-aminoethanol, another compound with potential pharmaceutical applications. The versatility of 3-(Trifluoromethyl)phenylacetone in undergoing reductive amination reactions makes it a valuable component in the synthesis of this compound.
Synthesis Reference(s)
The Journal of Organic Chemistry, 61, p. 1748, 1996 DOI: 10.1021/jo9518314Synthesis, p. 474, 1977
Check Digit Verification of cas no
The CAS Registry Mumber 21906-39-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,9,0 and 6 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21906-39:
(7*2)+(6*1)+(5*9)+(4*0)+(3*6)+(2*3)+(1*9)=98
98 % 10 = 8
So 21906-39-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H9F3O/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6H,5H2,1H3
21906-39-8Relevant articles and documents
POLYMORPH OF N-ETHYL-1-(3-(TRIFLUOROMETHYL)PHENYL)PROPAN-2-AMINE HYDROCHLORIDE AND PROCESS FOR PREPARATION THEREOF
-
Page/Page column 10, (2021/06/22)
The present invention relates to a crystalline form of N-ethyl-1-(3-(trifluoro methyl) phenyl) propan-2-amine hydrochloride compound of formula-1, which is represented by the following structural formula. The present invention also relates to process for the preparation of crystalline form of compound of formula-1 and process for the preparation of compound of formula-1.
Regio- and chemoselective rearrangement of terminal epoxides into methyl alkyl and aryl ketones
Tian, Yingying,Jürgens, Eva,Kunz, Doris
, p. 11340 - 11343 (2018/10/31)
The development of the highly active pincer-type rhodium catalyst 2 for the nucleophilic Meinwald rearrangement of functionalised terminal epoxides into methyl ketones under mild conditions is presented. An excellent regio- and chemoselectivity is obtained for the first time for aryl oxiranes.
Salicylic Acid-Catalyzed Arylation of Enol Acetates with Anilines
Felipe-Blanco, Diego,Gonzalez-Gomez, Jose C.
supporting information, p. 2773 - 2778 (2018/07/29)
α-Aryl ketones are both structure moieties commonly found in bioactive compounds and versatile synthetic intermediates for the preparation of drug-like molecules. An operationally simple and scalable protocol has been developed to prepare α-aryl ketones from readily available aromatic amines and enol acetates (or silyl enol ethers). This metal-free methodology features the use of salicylic acid as a convenient catalyst to promote the formation of aryl radicals from in-situ generated aryl diazonium salts, without demanding thermal or photochemical activation. The mild reaction conditions used are compatible with anilines substituted with diverse functionalities. Structural elaboration of some prepared α-aryl ketones was accomplished to illustrate their usefulness as building blocks. (Figure presented.).