21913-98-4

Basic information

• Product Name: 3''-METHOXYDAIDZEIN
• Synonyms: Isoflavone,4',7-dihydroxy-3'-methoxy- (8CI); 3'-Methoxydaidzein;4',7-Dihydroxy-3'-methoxyisoflavone
• CAS NO: 21913-98-4
• Molecular Formula: C₁₆H₁₂O₅
• Molecular Weight: 284.26348
• Product Categories: Iso-Flavones
• Mol File: 21913-98-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 258-260℃
• Boiling Point: 534.5°Cat760mmHg
• Flash Point: 204.8°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 4.87E-12mmHg at 25°C
• Refractive Index: 1.668
• PKA: 6.85±0.20(Predicted)
• CAS DataBase Reference: 3''-METHOXYDAIDZEIN(CAS DataBase Reference)
• NIST Chemistry Reference: 3''-METHOXYDAIDZEIN(21913-98-4)
• EPA Substance Registry System: 3''-METHOXYDAIDZEIN(21913-98-4)

Safety Data

• Hazardous Substances Data: 21913-98-4(Hazardous Substances Data)

Usage

Description

3''-METHOXYDAIDZEIN is a member of the class of 7-hydroxyisoflavones, specifically a 7,4'-dihydroxyisoflavone substituted by a methoxy group at position 3'. It is isolated from the heartwoods of Maackia amurensis subsp buergeri and Dalbergia louveli, exhibiting antiplasmodial activity.

Uses

Used in Pharmaceutical Industry:
3''-METHOXYDAIDZEIN is used as an active pharmaceutical ingredient for its antiplasmodial activity, which can be beneficial in the development of treatments for malaria.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, due to its potent antiproliferative activities, 3''-METHOXYDAIDZEIN could potentially be used as an anticancer agent in the development of treatments for various types of cancer.
Used in Drug Delivery Systems:
Similar to gallotannin, 3''-METHOXYDAIDZEIN could be employed in novel drug delivery systems to enhance its applications and efficacy against specific diseases, such as cancer or malaria. Various organic and metallic nanoparticles could be used as carriers for 3''-METHOXYDAIDZEIN delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.

InChI:InChI=1/C16H12O5/c1-20-15-6-9(2-5-13(15)18)12-8-21-14-7-10(17)3-4-11(14)16(12)19/h2-8,17-18H,1H3

Upstream product

• 137297-47-3 4',7-dihydroxy-3'-methoxyflavanone 
• 40456-49-3 1-(2,4-dihydroxyphenyl)-2-(4'-hydroxy-3'-methoxyphenyl)ethanone 
• 68-12-2 N,N-dimethyl-formamide 
• 121-33-5 vanillin 
• 128837-27-4 4-Ethoxymethoxy-3-methoxybenzaldehyde 
• 34000-39-0 homobutein 
• 16209-54-4 methyl 4-benzyloxy-3-methoxyphenylethanoate 
• 306-08-1 Homovanillic acid 
• 29973-91-9 4-benzyloxy-3-methoxyphenylacetic acid 
• 200127-80-6 3'-methoxydaidzin 
• 128837-31-0 4,4'-Di(ethoxymethoxy)-2'-hydroxy-3-methoxychalkone 

Downstream Products

• 124093-18-1 7-Hydroxy-3-(4-hydroxy-3-methoxy-phenyl)-chroman-4-one 
• 124093-21-6 (3R,4S)-3-(4-Hydroxy-3-methoxy-phenyl)-chroman-4,7-diol 

Relevant articles and documents

A Versatile Microbial System for Biosynthesis of Novel Polyphenols with Altered Estrogen Receptor Binding Activity

Isoflavonoids possess enormous potential for human health with potential impact on heart disease and cancer, and some display striking affinities for steroid receptors. Synthesized primarily by legumes, isoflavonoids are present in low and variable abundance within complex mixtures, complicating efforts to assess their clinical potential. To satisfy the need for controlled, efficient, and flexible biosynthesis of isoflavonoids, a three-enzyme system has been constructed in yeast that can convert natural and synthetic flavanones into their corresponding isoflavones in practical quantities. Based on the determination of the substrate requirements of isoflavone synthase, a series of natural and nonnatural isoflavones were prepared and their binding affinities for the human estrogen receptors (ERα and ERβ) were determined. Structure activity relationships are suggested based on changes to binding affinities related to small variations on the isoflavone structure.

Phenolic glucosides from the root of Pueraria lobata

Six phenolic glucosides were isolated from the methanolic extract of the root of Pueraria lobata. Three of them were new compounds and their structures were proved to be kuzubutenolide A, 3'-hydroxy-4'-O-β-D- glucosylpuerarin and 3'-methoxydaidzin.

Convenient synthesis of polyhydroxy flavonoids

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