21917-88-4

Basic information

• Product Name: 6,7-DIHYDRO-5H-ISOQUINOLIN-8-ONE
• Synonyms: 6,7-DIHYDRO-5H-ISOQUINOLIN-8-ONE;6,7-DIHYDROISOQUINOLIN-8(5H)-ONE;8(5H)-isoquinolinone,6,7-dihydro-;6,7-Dihydro-5H-Isoquinolinon-8-one;5,6,7,8-tetrahydroisoquinoline-5,8-dione;6,7-dihydro-8(5H)-Isoquinolinone;6,7-dihydroisoquinolin-8(5H)-one hydrochloride;6,7- two-5H- hydrogenisoquinoline-8- ketone
• CAS NO: 21917-88-4
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Product Categories: Isoquinoline Derivertives
• Mol File: 21917-88-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 42-44 °C
• Boiling Point: 266.169 °C at 760 mmHg
• Flash Point: 121.849 °C
• Appearance: /
• Density: 1.168 g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• PKA: 3.80±0.20(Predicted)
• CAS DataBase Reference: 6,7-DIHYDRO-5H-ISOQUINOLIN-8-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIHYDRO-5H-ISOQUINOLIN-8-ONE(21917-88-4)
• EPA Substance Registry System: 6,7-DIHYDRO-5H-ISOQUINOLIN-8-ONE(21917-88-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 21917-88-4(Hazardous Substances Data)

Usage

Description

6,7-Dihydro-5H-isoquinolin-8-one is an organic compound belonging to the isoquinolinone family. It is a heterocyclic compound with a unique chemical structure that features a fused pyridine and isoquinoline ring system. 6,7-DIHYDRO-5H-ISOQUINOLIN-8-ONE has attracted interest in various fields due to its potential applications and properties.

Uses

Used in Catalyst Preparation:
6,7-Dihydro-5H-isoquinolin-8-one is used as a catalyst in the study of the origins of catalysis in nornicotine aqueous aldol reactions. Its unique chemical structure allows it to facilitate and enhance the reaction process, making it a valuable component in the field of catalysis.
Used in Pharmaceutical Industry:
6,7-Dihydro-5H-isoquinolin-8-one is used as an intermediate in the synthesis of various pharmaceutical compounds. Its versatile chemical structure enables it to be a key component in the development of new drugs, particularly those targeting the central nervous system.
Used in Chemical Research:
6,7-DIHYDRO-5H-ISOQUINOLIN-8-ONE is also utilized in chemical research as a model system for studying the properties and reactivity of isoquinolinone derivatives. Its unique structure provides insights into the behavior of similar compounds and contributes to the advancement of chemical knowledge.

InChI:InChI=1/C9H9NO/c11-9-3-1-2-7-4-5-10-6-8(7)9/h4-6H,1-3H2

Upstream product

• 36556-06-6 5,6,7,8-tetrahydroisoquinoline 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 22971-46-6 5-oxo-5-(pyridin-3-yl)pentanoic acid 
• 87549-96-0 1-(pyridin-3-yl)cyclobutanol 
• 151330-02-8 methyl 6,7-dihydro-8(5H)-isoquinolinone-7-carboxylate 

Downstream Products

• 139484-32-5 5,6,7,8-tetrahydroisoquinolin-8-ol 
• 1338952-25-2 (E,Z)-8-(2-(3-Chlorophenyl)hydrazono)-5,6,7,8-tetrahydroisoquinoline 
• 36556-06-6 5,6,7,8-tetrahydroisoquinoline 
• 132725-67-8 8-benzyl-5,6,7,8-tetrahydro-isoquinoline 
• 113454-04-9 8-benzylidene-5,6,7,8-tetrahydro-isoquinoline 
• 139484-34-7 7,8-epoxy-5,6,7,8-tetrahydroisoquinoline 
• 139484-36-9 7,8-epoxy-7,8-dihydroisoquinoline 
• 1213648-37-3 5,6,7,8-tetrahydroisoquinolin-8-amine 
• 855268-64-3 8-benzyl-5,6,7,8-tetrahydro-isoquinolin-8-ol 
• 101584-53-6 8-(4-methoxy-benzyl)-5,6,7,8-tetrahydro-isoquinolin-8-ol 

Relevant articles and documents

ALPHA, BETA-UNSATURATED AMIDE COMPOUND

An object of the present invention is to provide an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like. The α,β-unsaturated amide compound represented by the following formula (I) or a pharmaceutically acceptable salt or the like thereof has anticancer activity and the like: [wherein, "A" represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents -O-, -S-, -SO2-, -NRX1- (wherein, RX1 represents hydrogen atom or lower alkyl), -CHRX2- (wherein, RX2 represents hydrogen atom or hydroxy), -CH=CH-, -CO- or -NH-CO-, and n1 and n2 are the same or different, and each represents 0 or 1].

Mercaptan compound having HDAC6 (histone deacetylase 6) inhibitory activity and application thereof

The invention belongs to the technical field of medicines and relates to a mercaptan compound having an anti-tumor activity, in particular to a mercaptan compound containing a 6(7)-substituted-N-(6-decylhexyl)-pyrazolo[3,4-e] indazole-3-formamide fragment

Tandem Oxidative Ring-Opening/Cyclization Reaction in Seconds in Open Atmosphere for the Synthesis of 1-Tetralones in Water-Acetonitrile

A mild and practical tandem oxidative ring-opening/cyclization reaction mediated by Ce4+ for the synthesis of 1-tetralones is presented. This rapid transformation was completed within 30 s and conducted in an open reactor at 0 °C in a water-acetonitrile mixture. Various cyclobutanol derivatives are transformed into desired products in good to high yields, and this reaction can be easily scaled up to the gram scale.