21928-51-8

Basic information

• Product Name: 5-Bromo-1,2,3-trichlorobenzene
• Synonyms: 3,4,5-Trichlorobromobenzene;5-Bromo-1,2,3-trichlorobenzene
• CAS NO: 21928-51-8
• Molecular Formula: C₆H₂BrCl₃
• Molecular Weight: 260.34
• EINECS: 1592732-453-0
• Mol File: 21928-51-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 60 ºC
• Boiling Point: 266 ºC
• Flash Point: 127 ºC
• Appearance: Off-white/Powder
• Density: 1.840
• Vapor Pressure: 0.0147mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Room temperature.
• Solubility: Chloroform, Methanol (Slightly)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-Bromo-1,2,3-trichlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-1,2,3-trichlorobenzene(21928-51-8)
• EPA Substance Registry System: 5-Bromo-1,2,3-trichlorobenzene(21928-51-8)

Safety Data

• Hazardous Substances Data: 21928-51-8(Hazardous Substances Data)

Usage

Description

5-Bromo-1,2,3-trichlorobenzene is an organic compound that features a benzene ring with one bromine atom and three chlorine atoms attached to it. It is a synthetic chemical used as an intermediate in various chemical reactions and has applications in the pharmaceutical and agrochemical industries.

Uses

Used in Pharmaceutical Industry:
5-Bromo-1,2,3-trichlorobenzene is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to be a key component in the development of new medications, contributing to the advancement of pharmaceutical research and drug discovery.
Used in Agrochemical Industry:
5-Bromo-1,2,3-trichlorobenzene is used as an intermediate in the preparation of isoxazole derivatives, which are effective in controlling parasites such as Rhipicephalus sanguineous nymphs. These derivatives play a crucial role in the development of new pesticides and other agrochemical products to protect crops and livestock from harmful parasites.

InChI:InChI=1/C6H2BrCl3/c7-3-1-4(8)6(10)5(9)2-3/h1-2H

Upstream product

• 2106-38-9 3,4,5-trichlorobenzenediazonium tetrafluoroborate 
• 62-53-3 aniline 
• 106-40-1 4-bromo-aniline 
• 63-74-1 sulfanilamide 
• 22134-75-4 4-amino-3,5-dichloro-benzenesulfonamide 
• 81067-37-0 1-bromo-2,3,4-trichlorobenzene 
• 87-61-6 1,2,3-trichlorobenzene 
• 915144-98-8 2,3,4-trichloro-1,5-phenylenebis(trimethylsilane) 
• 915144-97-7 trimethyl(2,3,4-trichlorophenyl)silane 
• 811720-26-0 1,5-dibromo-2,3,4-trichlorobenzene 
• 697-88-1 4-bromo-2,6-dichloroaniline 

Downstream Products

• 34328-39-7 3,4,5-Trichlor-4'-trifluormethylbenzophenon 
• 51-39-8 3,4,5-trichlorobenzoic acid 
• 51693-89-1 1,2,3-Trichloro-5-[1-(4-fluoro-phenyl)-1-methyl-ethyl]-benzene 
• 1253853-26-7 4-chlorophenyl-3,4,5-trichlorophenylselenide 
• 158401-00-4 1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone 
• 1398110-63-8 tetrahydrofuran-3-carboxylic acid {2-methyl-5-[5-(3,4.5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3ylmethyl}amide 
• 1398110-90-1 2-methyl-5-[4,4,4-trifluoro-3-hydroxy-3-(3,4,5-trichlorophenyl)butyryl]furan-3-carboxylic acid methyl ester 
• 1398110-91-2 (E/Z)-2-methyl-5-[4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl]furan-3-carboxylic acid methyl ester 
• 1398110-92-3 2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-carboxylic acid methyl ester 
• 1398110-93-4 {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]furan-3-yl}methanol 
• 1398110-94-5 2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde 
• 1398110-64-9 {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}carbamic acid tert-butyl ester 
• 1398110-65-0 C-{2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-yl}methylamine 
• 1398110-62-7 cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide 

Relevant articles and documents

PROCESS FOR PREPARATION OF 5-BROMO-1, 2, 3-TRICHLOROBENZENE

The present invention relates to a process for preparation of 5-bromo-1,2,3-trichlorobenzene of formula (I) in simple, economical manner with high yield. The 5-bromo-1,2,3-trichlorobenzene of formula (I) is used in preparation of 1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone which is a key intermediate of isoxazoline derivatives. (I)

PROCESS FOR THE PREPARATION OF 5-BROMO-1,2,3-TRICHLOROBENZENE

The present invention relates to a process for the preparation of a compound of formula I (I), comprising reacting a compound of formula II (II), with a brominating agent in the presence of an acidic catalyst to a compound of formula III (III), and reacti

Catalytic Sandmeyer bromination

An efficient catalyst system for Sandmeyer bromination is proposed. Aryl bromides and dibromides can be obtained with excellent yield by this synthetic protocol. Georg Thieme Verlag Stuttgart.