219547-43-0Relevant articles and documents
Thieno[2,3-d]pyrimidine-3-acetic acids a new class of nonpeptide endothelin receptor antagonists
Cho, Nobuo,Nara, Yoshi,Harada, Mioko,Sugo, Tsukasa,Masuda, Yasushi,Abe, Akemi,Kusumoto, Keiji,Itoh, Yasuaki,Ohtaki, Tetsuya,Watanabe, Toshifumi,Furuya, Shuichi
, p. 1724 - 1737 (2007/10/03)
On the basis of structural information for the cyclic hexapeptide endothelin (ET) receptor antagonist, TAK-044, a series of thieno[2,3- d]pyrimidine-2,4-dione derivatives bearing a carboxyl group and aromatic rings that were important for receptor binding