21962-45-8

Basic information

• Product Name: 4-CYANO-2-METHOXYBENZALDEHYDE
• Synonyms: 4-CYANO-2-METHOXYBENZALDEHYDE;4-Cyaon-2-methoxybenzaldehyde;2-Methoxy-4-cyanobenzaldehyde;4-forMyl-3-Methoxybenzonitrile;4-ForMyl-3-Methoxybenzonitrile(2-Methoxy-4-cyanobenzaldehyde)
• CAS NO: 21962-45-8
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol File: 21962-45-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 109-111℃
• Boiling Point: 318℃
• Flash Point: 138℃
• Appearance: /
• Density: 1.18
• Vapor Pressure: 0.000368mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-CYANO-2-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-2-METHOXYBENZALDEHYDE(21962-45-8)
• EPA Substance Registry System: 4-CYANO-2-METHOXYBENZALDEHYDE(21962-45-8)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 21962-45-8(Hazardous Substances Data)

Usage

General Description

4-Cyano-2-methoxybenzaldehyde is a chemical compound with the molecular formula C9H7NO2. It is also known by its other names, such as 4-Formyl-2-methoxybenzonitrile or 2-Methoxy-4-formylbenzonitrile. This organic compound falls under the benzonitrile group. 4-Cyano-2-methoxybenzaldehyde presents as a light yellow crystal or powder and is largely used in the synthesis of other complex compounds, demonstrating its relevance in organic chemistry. It is crucial to handle it under controlled circumstances as it has the potential to cause skin and eye irritation, and may also lead to respiratory issues if inhaled.

InChI:InChI=1/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3

Upstream product

• 959934-76-0 tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate 
• 87808-44-4 3-methoxy-4-methylbenzoyl chloride 
• 7151-68-0 3-methoxy-p-toluic acid 
• 43192-33-2 4-bromo-2-methoxybenzaldehyde 
• 139102-34-4 methyl 4-bromo-2-methoxybenzoate 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 139102-37-7 4-iodo-2-methoxybenzaldehyde 
• 38170-02-4 4-iodosalicylaldehyde 
• 626-02-8 3-Iodophenol 
• 890038-13-8 4-(hydroxymethyl)-3-methoxybenzonitrile 
• 3556-60-3 3-methoxy-4-methylcyano-benzene 

Downstream Products

• 959984-40-8 4-(4-cyano-2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile 
• 959984-54-4 4-(4-cyano-2-methoxyphenyl)-5-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile 
• 959984-56-6 4-(4-cyano-2-methoxyphenyl)-2,7-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile 
• 959984-57-7 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile 
• 1404065-33-3 C₂₀H₂₁N₅O₂ 
• 1050477-31-0 BAY₉₄₈₈₆₂ 
• 914105-85-4 5-(4-cyano-2-methoxyphenyl)-3-(3-cyanophenyl)isoxazole 
• 914105-84-3 5-(4-cyano-2-methoxyphenyl)-3-(4-cyanophenyl)isoxazole 
• 914105-74-1 2,3-dibromo-3-(4-cyano-2-methoxyphenyl)-1-(3-cyanophenyl)propan-1-one 
• 914105-73-0 2,3-dibromo-3-(4-cyano-2-methoxyphenyl)-1-(4-cyanophenyl)propan-1-one 
• 914104-61-3 3,5-bis[4-(N-acetoxy)amidino-2-methoxyphenyl]isoxazole 
• 914104-59-9 3,5-bis[4-(N'-hydroxy)amidino-2-methoxyphenyl]isoxazole 

Relevant articles and documents

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND RECOVERY OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE BY ELECTROCHEMICAL METHODS

The present invention relates to a novel process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and recovering (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) proceeding from (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula ent-(I)

Synthesis method of 2-methoxyl-4-cyanobenzaldehyde

The invention discloses a synthesis method of 2-methoxyl-4-cyanobenzaldehyde. The method comprises the following steps: 1, carrying out acylating chlorination on 4-methyl-3-methoxybenzoic acid servingas a raw material, and then carrying out aminolysis to

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

1,6-Naphthyridine or 8-azaquinazoline derivatives (I) are new. 1,6-Naphthyridine or 8-azaquinazoline derivatives of formula (I) are new. D : N or CR 4>; R 4> : H, F, CF 3 or 1-4C alkyl; Ar : 5-R 5>-6-R 6>-2-methyl-4-oxo-4H-1-benzopyran-8-yl; 3-R 6>-4-R 8>-1-naphthyl optionally substituted with 1-3 of R 7>; 7-R 6>-8-R 8>-5-quinolinyl optionally substituted with 1-2 of R 7>; or 2-R 9>-3-R 10>-4-R 8>-5-R 6>-phenyl; R 5> : H, F, Cl, CN, NO 2, CF 3 or 1-4C alkyl; R 6> : H or F; R 7> : halo, 1-4C alkyl, CF 3, 1-4C alkoxy or OCF 3; R 8> : CN or NO 2; R 9> : H or halo; optionally fluorinated 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio of di(1-4C alkyl)amino; or phenyl optionally substituted with halo, 1-4C alkyl or CF 3; R 10> : H, halo or 1-4C alkyl; R 1> : optionally fluorinated 1-4C alkyl; R 2> : 1-6C alkyl optionally substituted with 3-7C cycloalkyl or F; or SO 2R 11>; R 11> : 1-6C alkyl, CF 3 or 3-7C cycloalkyl; or phenyl or heteroaryl optionally substituted with 1-2 of halo, CN, 1-4C alkyl, CF 3, 1-4C alkoxy and/or OCF 3; R 3> : H, F, CF 3 or 1-4C alkyl. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Hypotensive; Cardiant; Hepatotropic; Nephrotropic; Cerebroprotective. MECHANISM OF ACTION : Mineralocorticoid receptor (MR) antagonist. 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide had an IC 50 of 35 nM when tested on cells expressing a GAL4-MR chimera.