219679-74-0

Basic information

• Product Name: 3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole
• Synonyms: 3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole
• CAS NO: 219679-74-0
• Molecular Weight: 281.378
• Mol File: 219679-74-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole(219679-74-0)
• EPA Substance Registry System: 3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole(219679-74-0)

Safety Data

• Hazardous Substances Data: 219679-74-0(Hazardous Substances Data)

Upstream product

• 35370-99-1 bis-(4-methylsulfanyl-phenyl)-ether 

Downstream Products

• 181695-98-7 3-methyl-4-(4-methylsulfonylphenyl)-5-phenylisoxazole 
• 181695-93-2 3-methyl-5-(4-methylsulfonylphenyl)-4-phenylisoxazole 
• 181695-95-4 4-[5-(3-chlorophenyl)-3-methylisoxazol-4-yl]benzenesulfonamide 
• 181695-85-2 4-(3-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide 
• 181696-12-8 4-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide 
• 181696-17-3 4-[5-difluoromethyl-3-(4-methylphenyl)isoxazol-4-yl]benzenesulfonamide 
• 181696-16-2 4-[5-difluoromethyl-3-(4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide 
• 181696-15-1 4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide 

Relevant articles and documents

NHC-palladium-catalyzed ionic liquid-accelerated regioselective oxyarylation of alkynes with diaryl ethers?

The first NHC-palladium-catalyzed regioselective oxyarylation of oxime ether in a task-specific ionic liquid via C(sp3)-O and C(sp2)-O bond cleavage of two different types of ethers for the assembly of structurally diverse 4-arylisoxazoles is described. Both the basic ionic liquid [C3NH2mim]Br and NHC-Pd catalyst IPr-Pd-Im-Cl2 played an important role in this transformation. Notably, this new approach provides a practical and straightforward route to access a broad range of privileged 4-arylisoxazole structures with good yields and excellent regioselectivities. Significantly, this catalytic system can be recycled up to eight times without significant loss of catalytic activity.