219685-50-4

Basic information

• Product Name: Unii-A3ulp0F556
• Synonyms: Alexion;Eculizumab;H5G1.1;H5G1.1Vhc H5G1.1vlc;Soliris;Unii-A3ulp0F556;ECULIZUMABUM;IMMunoglobulin,anti-(huMan coMpleMent C5 a-chain) (huMan-Mouse Monoclonal 5G1.1 heavy chain), disulfide withhuMan-Mouse Monoclonal 5G1.1 light chain, diMer (9CI)
• CAS NO: 219685-50-4
• Mol File: 219685-50-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Unii-A3ulp0F556(CAS DataBase Reference)
• NIST Chemistry Reference: Unii-A3ulp0F556(219685-50-4)
• EPA Substance Registry System: Unii-A3ulp0F556(219685-50-4)

Safety Data

• Hazardous Substances Data: 219685-50-4(Hazardous Substances Data)

Usage

Description

Unii-A3ulp0F556, also known as Glycerol, is a simple polyol compound that is widely used in various industries due to its unique properties. It is a colorless, odorless, and viscous liquid with a sweet taste. Glycerol is hygroscopic, which means it can absorb moisture from the environment, and it is also a versatile solvent for various substances. Its chemical formula is C3H8O3.

Uses

Used in Pharmaceutical Industry:
Unii-A3ulp0F556 is used as a solvent for various pharmaceutical formulations, including elixirs, syrups, and liquid medications. It serves as a base for these formulations, providing a medium for the active ingredients to dissolve and be delivered effectively.
Used in Cosmetics and Personal Care Industry:
In the cosmetics and personal care industry, Unii-A3ulp0F556 is used as a humectant to help retain moisture in skin and hair care products. It is also used as a solvent for various ingredients in cosmetics, such as fragrances, dyes, and other additives.
Used in Food Industry:
Unii-A3ulp0F556 is used as a humectant in the food industry to retain moisture in products like candies, baked goods, and confectionery items. It also acts as a thickening agent and helps maintain the texture and consistency of these products.
Used in Automotive Industry:
In the automotive industry, Unii-A3ulp0F556 is used as a component in the manufacturing of antifreeze and coolant solutions. It helps lower the freezing point of the solution and raises the boiling point, providing better protection for the engine in extreme temperatures.
Used in Industrial Applications:
Unii-A3ulp0F556 is used as a raw material in the production of various chemicals, such as glycerol esters, glycerol ethers, and other derivatives. These compounds find applications in various industries, including plastics, textiles, and lubricants.
Used in Energy Industry:
In the energy industry, Unii-A3ulp0F556 is used as a feedstock for the production of biodiesel and other biofuels. It can also be used as a blending component in the formulation of diesel fuel, improving its properties and reducing emissions.
Used in Treatment of Autoimmune Diseases:
Unii-A3ulp0F556 is used in the treatment of autoimmune diseases such as rheumatoid arthritis, membranous nephritis, lupus nephritis, dermatomyositis, and autoimmune hemolytic anemias. It helps alleviate symptoms and improve the quality of life for patients suffering from these conditions.

Originator

Alexion (US)

Clinical Use

Recombinant monoclonal antibody:Paroxysmal nocturnal haemoglobinuria (PNH)Atypical haemolytic uraemic syndrome (aHUS)Refractory generalized myasthenia gravis (gMG) in patients who are anti-acetylcholine receptor (AChR) antibody-positive (MG)

Metabolism

Human antibodies undergo endocytotic digestion in the cells of the reticuloendothelial system. Eculizumab contains only naturally occurring amino acids and has no known active metabolites. Human antibodies are predominately catabolised by lysosomal enzymes to small peptides and amino acids.