219711-56-5Relevant articles and documents
Novel method for synthesis and antimicrobial activity of 2-arylsulpho-6-hydroxy/chloro/hydrazino/carboxy-methoxy-3(2H)-pyridazinones
Purohit, D. M.,Shah, V. H.
, p. 956 - 960 (2007/10/03)
The title compounds 2-arylsulpho-6-hydroxy/chloro/hydrazino/carboxymethoxy-3(2H)-pyridazinones 1-4 have been synthesised. The chemoselective cyclocondensation of maleoyl chloride with arylsulphonyl hydrazides gives 1a-o. Compounds 1a-o on chlorination with POCl3 give 2a-o which on reaction with hydrazine hydrate give 3a-o. Compounds 1a-o on reaction with ClCH2COOH in aq. NaOH furnish 4a-o. The structures of the products have been delineated by elemental analyses and spectral data. Antimicrobial activities have also been studied.