21977-09-3

Basic information

• Product Name: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE
• Synonyms: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE;2-Morpholinoacetaldehyde;4-Morpholine acetaldehyde;Morpholin-4-ylacetaldehyde hydrochloride;4-Morpholineacetaldehyde HCl H2O
• CAS NO: 21977-09-3
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• Mol File: 21977-09-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 308.4 °C at 760 mmHg
• Flash Point: 140.3 °C
• Appearance: /
• Density: 1.046 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.31±0.10(Predicted)
• CAS DataBase Reference: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE(21977-09-3)
• EPA Substance Registry System: MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE(21977-09-3)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 21977-09-3(Hazardous Substances Data)

Usage

General Description

MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE is a chemical compound that is commonly used in the pharmaceutical industry. It is a hydrochloride salt of morpholin-4-yl-acetaldehyde monohydrate, which is a derivative of morpholine. MORPHOLIN-4-YL-ACETALDEHYDE MONOHYDRATE HYDROCHLORIDE is used as an intermediate in the synthesis of various drugs and pharmaceuticals. It is also used as a reagent in organic synthesis and in the production of other chemical compounds. The hydrochloride salt form of this compound is generally more stable and easier to handle than the free base form. It is important to handle this chemical with proper safety measures and precautions, as it can be hazardous if not used and stored properly.

Upstream product

• 3616-59-9 4-(2,2-diethoxy-ethyl)-morpholine 
• 22633-57-4 4-(2,2-dimethoxyethyl)morpholine 

Relevant articles and documents

Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline as potential EGFR inhibitors

Eight series of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline were designed, synthesized and evaluated for the IC50 values against three cancer cell lines (A549, MCF-7 and PC-3). Most of the forty nine target compounds showed excellent antiproliferative activity against one or several cancer cell lines. The compound 13a showed the best activity against A549, MCF-7 and PC-3 cancer cell lines, with the IC50 values of 1.09 ± 0.04 μM, 1.34 ± 0.13 μM and 1.23 ± 0.09 μM, respectively. Eight selected compounds were further selected to evaluated for the inhibitory activity against EGFR kinase. Three of them showed equal activity against EGFR kinase to positive control afatinib. AnnexinV-FITC, propidium iodide (PI) double staining and acridine orange single staining results indicated that the compound 13a could induce apoptosis of human lung cancer A549 cells.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.