219843-76-2 Usage
Description
Androst-16-en-3-ol, 17-(3-pyridinyl)-, acetate (ester),(3β,5α)is a complex organic compound with a unique molecular structure, characterized by the presence of a 16-en-3-ol group and a 17-(3-pyridinyl) substituent. This molecule is an ester derivative, specifically an acetate ester, which is formed by the reaction of the hydroxyl group of the parent alcohol with acetic acid. The compound exhibits a 3β,5α stereochemistry, which is crucial for its biological activity and potential applications.
Uses
Used in Pharmaceutical Industry:
Androst-16-en-3-ol, 17-(3-pyridinyl)-, acetate (ester),(3β,5α)is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly those targeting hormonal imbalances and related conditions. Its unique structure allows for the development of novel therapeutic agents with improved efficacy and selectivity.
Used in Prostate Cancer Therapy:
In the field of prostate cancer treatment, Androst-16-en-3-ol, 17-(3-pyridinyl)-, acetate (ester),(3β,5α)is used as a precursor for the preparation and activity of abiraterone metabolites. These metabolites play a crucial role in redirecting abiraterone metabolite to fine-tune prostate cancer anti-androgen therapy, potentially leading to more effective treatment strategies for patients.
Used in Drug Delivery Systems:
Similar to gallotannin, Androst-16-en-3-ol, 17-(3-pyridinyl)-, acetate (ester),(3β,5α)may also be employed in the development of innovative drug delivery systems. These systems could enhance the compound's bioavailability, delivery, and therapeutic outcomes, particularly in the context of hormone-related disorders and cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 219843-76-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,8,4 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 219843-76:
(8*2)+(7*1)+(6*9)+(5*8)+(4*4)+(3*3)+(2*7)+(1*6)=162
162 % 10 = 2
So 219843-76-2 is a valid CAS Registry Number.
219843-76-2Relevant articles and documents
Abiraterone acetate reducing impurity and preparation method thereof
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, (2017/10/22)
The invention discloses an abiraterone acetate reducing impurity and a preparation method thereof. The impurity is 17-(3-pyridyl) androstane-3 beta-acetoxyl. The preparation method of the impurity includes the steps: taking dehydroepiandrosterone as a starting material; performing catalytic hydrogenation by palladium carbon to obtain (3 beta)-3-hydroxy-17-sterone; performing reaction by hydrazine hydrate to obtain 17-hydrazono-androstane-3 beta-alcohol; performing iodine substitution to obtain 17-iodine-androstane-3 beta-alcohol; reacting the 17-iodine-androstane-3 beta-alcohol with borane reagents under palladium catalysis to obtain 17-(3-pyridyl) androstane-3 beta-alcohol; performing acetic anhydride acetylation to obtain the abiraterone acetate reducing impurity 17-(3-pyridyl) androstane-3 beta-acetoxyl.
ALTERING STEROID METABOLISM FOR TREATMENT OF STEROID-DEPENDENT DISEASE
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, (2016/09/26)
A method of treating steroid-dependent disease such as prostate cancer in a subject is described that includes administering a therapeutically effective amount a CYP17A inhibitor and an effective amount of a 5- -reductase inhibitor to the subject.
