219870-45-8

Basic information

• Product Name: 2-tert-butoxycarbonylamino-4-(dimethyl-phenyl-silanyl)-butyric acid
• Synonyms: 2-tert-butoxycarbonylamino-4-(dimethyl-phenyl-silanyl)-butyric acid
• CAS NO: 219870-45-8
• Molecular Weight: 337.491
• Mol File: 219870-45-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-tert-butoxycarbonylamino-4-(dimethyl-phenyl-silanyl)-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butoxycarbonylamino-4-(dimethyl-phenyl-silanyl)-butyric acid(219870-45-8)
• EPA Substance Registry System: 2-tert-butoxycarbonylamino-4-(dimethyl-phenyl-silanyl)-butyric acid(219870-45-8)

Safety Data

• Hazardous Substances Data: 219870-45-8(Hazardous Substances Data)

Upstream product

• 219870-32-3 tert-butyl (4R)-2,2-dimethyl-4-(3-methyl-3-phenyl-3-silabutyl)-1,3-oxazolidine-3-carboxylate 
• 219870-21-0 tert-butyl (4R)-4-((1E)-3-methyl-3-phenyl-3-silabut-1-enyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 162107-48-4 tert-butyl (R)-4-ethynyl-2,2-dimethyloxazolidine-3-carboxylate 
• 219870-38-9 N-[(1R)-2-hydroxy-1-(3-methyl-3-phenyl-3-silabutyl)ethyl](tert-butoxy)carboxamide 

Downstream Products

• 67198-86-1 (R)-2-[(tert-butoxycarbonyl)amino]butano-4-lactone 
• 258351-86-9 methyl (2R)-2-[(tert-butoxy)carbonylamino]-4-hydroxybutanoate 
• 219870-51-6 methyl (2R)-2-[(tert-butoxy)carbonylamino]-5-methyl-5-phenyl-5-silahexanoate 

Relevant articles and documents

Silylcupration of (R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4- ethynyloxazolidine: A stereoselective approach to the synthesis of γ- silylated saturated and unsaturated α-amino acids

Enantioselective synthesis of γ-silylated amino acids is reported, using a four-step procedure based on the silylcupration of ethynyloxazolidine 2. Silylcuprates 6a-c are highlighted as useful reagents to be employed with enantiomerically enriched substrates. Vinylsilanes 5 are easily prepared and highlighted as useful intermediates to yield the final compounds after reduction, opening of the oxazolidine ring, and oxidation. Moreover, β,γ- unsaturated amino acids are obtained as very interesting vinylglycine derivatives. The capability of silicon-containing amino acids to be incorporated into dipeptides is also shown.