219943-38-1

Basic information

• Product Name: 3,4-DIBROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3,4-DIBROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;3,4-DIBROMOINDOLE, N-BOC PROTECTED;3,4-Dibromo-1H-indole, N-BOC protected;3,4-Dibromo-1H-indole-1-carboxylic acid tert-butyl ester;3,4-Dibromo-1H-indole, N-BOC protected 98%;1-Boc-3,4-dibromoindole;Zinc02563790;3,4-Dibromo-1H-indole,N-BOCprotected98%
• CAS NO: 219943-38-1
• Molecular Formula: C₁₃H₁₃Br₂NO₂
• Molecular Weight: 375.06
• Mol File: 219943-38-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 414.518 °C at 760 mmHg
• Flash Point: 204.494 °C
• Appearance: /
• Density: 1.64g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,4-DIBROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIBROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(219943-38-1)
• EPA Substance Registry System: 3,4-DIBROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(219943-38-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 219943-38-1(Hazardous Substances Data)

Usage

General Description

3,4-Dibromoindole-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C14H15Br2NO2. It is a tert-butyl ester derivative of 3,4-dibromoindole-1-carboxylic acid. 3,4-DIBROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER has been studied for its potential pharmaceutical and biological applications, including its use as a potential intermediate in the synthesis of biologically active compounds. Its structure and properties make it of interest for researchers in the fields of organic chemistry, medicinal chemistry, and pharmaceutical development.

InChI:InChI=1/C13H13Br2NO2/c1-13(2,3)18-12(17)16-7-9(15)11-8(14)5-4-6-10(11)16/h4-7H,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 219943-37-0 3,4-dibromo-1H-indole 
• 146886-51-3 1-(N-triisopropylsilyl-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 146886-59-1 (4-bromo-1-triisopropylsilyl-1H-indol-3-ylmethyl)-dimethylamine 
• 406170-05-6 3,4-dibromo-1-triisopropylsilanyl-1H-indole 
• 52488-36-5 4-bromo-1H-indole 

Downstream Products

• 219943-53-0 (R)-4-bromo-α-N-trityltryptophan methyl ester 
• 219943-51-8 (R)-4-bromo-α-N-trityltryptophan 
• 219943-61-0 (R)-4-bromotryptophan 
• 219943-50-7 (R)-4-bromo-α-N-trityltryptophan trityl ester 
• 219943-42-7 4-Bromo-3-[(S)-3-methoxymethoxy-2-(9-phenyl-9H-fluoren-9-ylamino)-propionyl]-indole-1-carboxylic acid tert-butyl ester 
• 219943-45-0 4-Bromo-3-[(R)-3-methoxymethoxy-2-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-indole-1-carboxylic acid tert-butyl ester 
• 219943-49-4 (R)-4-bromo-1-(tert-butyloxycarbonyl)-α-N-(9-phenyl-9-fluorenyl)tryptophan 
• 219943-46-1 4-Bromo-3-[(R)-3-hydroxy-2-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-indole-1-carboxylic acid tert-butyl ester 
• 219943-47-2 4-Bromo-3-[(R)-3-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-indole-1-carboxylic acid tert-butyl ester 
• 219943-44-9 [(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine 

Relevant articles and documents

Rapid route to 3,4-substituted indoles via a directed ortho metalation-retro-Mannich sequence.

[reaction: see text] In the presence of NXS (X = Br, I, Cl), gramine derivatives 1, derived by combined directed ortho metalation (DoM)-cross-coupling sequences, rapidly undergo retro-Mannich fragmentation (2) to afford 3-halo indoles 3 in 37-88% yields.