219967-74-5 Usage
Description
Fmoc-(S)-3-amino-5-phenylpentanoic acid is a chiral, synthetic amino acid derivative that features a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group and a phenyl ring. FMOC-(S)-3-AMINO-5-PHENYLPENTANOIC ACID is characterized by its specific stereochemistry, with the (S)-configuration at the 3-position, which is crucial for its reactivity and selectivity in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
Fmoc-(S)-3-amino-5-phenylpentanoic acid is used as an intermediate in the synthesis of chemical modulators of heat shock protein 70 (Hsp70) for the development of potential therapeutic agents. Hsp70 is a molecular chaperone that plays a critical role in protein folding, assembly, and stabilization, and its modulation can have significant implications in the treatment of various diseases, including neurodegenerative disorders and cancer.
Used in Organic Synthesis:
Fmoc-(S)-3-amino-5-phenylpentanoic acid is utilized in the preparation of guanidinoglycosides through the inventive use of Mitsunobu conditions and diazabicycloundecene. These guanidinoglycosides are valuable building blocks in organic synthesis, particularly for the construction of complex carbohydrate structures and bioactive molecules. The unique structural features of Fmoc-(S)-3-amino-5-phenylpentanoic acid, such as the Fmoc protecting group and the phenyl ring, enable selective reactions and facilitate the synthesis of diverse chemical entities with potential applications in medicinal chemistry and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 219967-74-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,9,6 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 219967-74:
(8*2)+(7*1)+(6*9)+(5*9)+(4*6)+(3*7)+(2*7)+(1*4)=185
185 % 10 = 5
So 219967-74-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H25NO4/c28-25(29)16-19(15-14-18-8-2-1-3-9-18)27-26(30)31-17-24-22-12-6-4-10-20(22)21-11-5-7-13-23(21)24/h1-13,19,24H,14-17H2,(H,27,30)(H,28,29)/t19-/m0/s1
219967-74-5Relevant articles and documents
(S)-β3-homolysine- and (S)-β3-homoserine-containing β-peptides: CD spectra in aqueous solution
Abele, Stefan,Guichard, Gilles,Seebach, Dieter
, p. 2141 - 2156 (2007/10/03)
For further structural studies and for physiological investigations of β-peptides, it is necessary to have H2O-soluble derivatives. Thus, we have prepared β-hexa-, β-hepta-, and β-nonapeptides (1-6) with two, three, and seven side chains of lys
