219982-82-8Relevant articles and documents
Synthesis of 5-(carboranylalkylmercapto)-2'-deoxyuridines and 3- (carboranylalkyl)thymidines and their evaluation as substrates for human thymidine kinases 1 and 2
Lunato, Anthony J.,Wang, Jianghai,Woollard, Jeffrey E.,Anisuzzaman, Abul K. M.,Ji, Weihua,Rong, Feng-Guang,Ikeda, Seiichiro,Soloway, Albert H.,Eriksson, Staffan,Ives, David H.,Blue, Thomas E.,Tjarks, Werner
, p. 3378 - 3389 (1999)
Derivatives of thymidine containing o-carboranylalkyl groups at the N-3 position and derivatives of 2'-deoxyuridine containing o- carboranylalkylmercapto groups at the C-5 position were synthesized. The alkyl spacers consist of 4-8 methylene units. The sy
NOVEL LYSOPHOSPHATIDIC ACID DERIVATIVE
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Paragraph 0301-0303, (2021/05/28)
PROBLEM TO BE SOLVED: To provide a compound that specifically activates an LPA4 receptor, and a pharmaceutical composition containing the same. SOLUTION: This invention relates to a novel lysophosphatidic acid derivative that has an agonistic action on an LPA4 receptor and is useful for the prevention and/or treatment of a disease with angiodysplasia caused by the LPA4 receptor, or a disease associated with angiopathy, or symptoms associated therewith. This invention also relates to a pharmaceutical composition containing the lysophosphatidic acid derivative. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Fused ring aziridines as a facile entry into triazole fused tricyclic and bicyclic heterocycles
Fang, Fang,Vogel, Megan,Hines, Jennifer V.,Bergmeier, Stephen C.
scheme or table, p. 3080 - 3091 (2012/05/07)
The intramolecular dipolar cycloaddition of an azide with an alkyne has provided a useful entry into triazole fused tricyclic heterocycles containing both the triazole ring and the oxazolidin-2-one ring system. The requisite azido-alkynes have been prepared via a two-step sequence from fused ring aziridines. A series of 6-12 membered rings containing both the oxazolidinone and triazole rings have been prepared. These ring systems have been designed as conformationally restrained analogs of RNA-binding oxazolidinones. The Royal Society of Chemistry 2012.