22003-30-1 Usage
Description
1-(2'-deoxyribosyl)-2-pyrimidinone, also known as β-2'-Deoxy Zebularine, is a metabolite derived from Zebularine (Z276000). It is a compound with significant biological activity and potential applications in various fields due to its unique chemical properties and interactions with biological systems.
Uses
Used in Pharmaceutical Industry:
1-(2'-deoxyribosyl)-2-pyrimidinone is used as an inhibitor for human deoxycytidine deaminase (hDCTD) for its ability to inhibit the enzyme's activity. This inhibition can have therapeutic implications in the treatment of certain diseases and conditions where the regulation of hDCTD is crucial.
Used in Anticancer Applications:
As a metabolite of Zebularine, 1-(2'-deoxyribosyl)-2-pyrimidinone may also have potential applications in cancer research and treatment. Its ability to inhibit hDCTD could be explored for its effects on cancer cell growth and proliferation, potentially leading to the development of novel anticancer drugs or therapies.
Used in Research and Development:
1-(2'-deoxyribosyl)-2-pyrimidinone can be utilized in research settings to study the mechanisms of hDCTD and its role in various biological processes. 1-(2'-deoxyribosyl)-2-pyrimidinone can serve as a valuable tool for scientists to investigate the effects of hDCTD inhibition on cellular functions and the potential therapeutic benefits of such inhibition.
Check Digit Verification of cas no
The CAS Registry Mumber 22003-30-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,0,0 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 22003-30:
(7*2)+(6*2)+(5*0)+(4*0)+(3*3)+(2*3)+(1*0)=41
41 % 10 = 1
So 22003-30-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2O4/c12-5-7-6(13)4-8(15-7)11-3-1-2-10-9(11)14/h1-3,6-8,12-13H,4-5H2/t6-,7+,8-/m0/s1
22003-30-1Relevant articles and documents
Efficient synthesis of 2′-deoxyzebularine and its α-anomer by the silyl method of N-glycosylation. Crystal structures and conformational study in solution
Ebenryter-Olbinska, Katarzyna,Karolak-Wojciechowska, Janina,Sochacka, Elzbieta
, p. 7 - 15 (2014/05/20)
2′-Deoxyzebularine and its α-anomer have been efficiently synthesized with relatively high stereoselectivity by a modified procedure of the silyl method of the N-glycosidic bond formation. An SnCl4- catalyzed condensation of silylated pyrimidin
Nucleoside und Nucleotide. Teil 15. Synthese von Desoxyribonucleosid-monophosphaten und -triphosphaten mit 2(1H)-Pyrimidinon, 2(1H)-Pyridinon und 4-Amino-2(1H)-pyridinon als Basen
Kohler, Peter,Wachtl, Michael,Tamm, Christoph
, p. 2488 - 2494 (2007/10/02)
The phosphorylation of the modified nucleosides 1-(2'-deoxy-β-D-ribofuranosyl)-2(1H)-pyrimidinone (Md, 4), 4-amino-1-(2'-deoxy-β-D-ribofuranosyl)-2(1H)-pyridinone (Zd, 6) and the synthesis of 1-(2'-deoxy-β-D-ribofuranosyl)-2(1H)-pyri
