220040-48-2

Basic information

• Product Name: methyl 6-(chloromethyl)pyridine-2-carboxylate
• Synonyms: methyl 6-(chloromethyl)pyridine-2-carboxylate;6-CHLOROMETHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;Methyl 6-(chloroMethyl)picolinate;2-Pyridinecarboxylic acid,6-(chloromethyl)-,methyl ester
• CAS NO: 220040-48-2
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 220040-48-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 303.4°C at 760 mmHg
• Flash Point: 137.3°C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 0.000935mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: 2-8°C
• PKA: 0.70±0.10(Predicted)
• CAS DataBase Reference: methyl 6-(chloromethyl)pyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-(chloromethyl)pyridine-2-carboxylate(220040-48-2)
• EPA Substance Registry System: methyl 6-(chloromethyl)pyridine-2-carboxylate(220040-48-2)

Safety Data

• Hazardous Substances Data: 220040-48-2(Hazardous Substances Data)

Usage

General Description

Methyl 6-(chloromethyl)pyridine-2-carboxylate is a chemical compound with the molecular formula C9H8ClNO2. It is a pyridine derivative that contains a methyl ester and a chloromethyl group. methyl 6-(chloromethyl)pyridine-2-carboxylate is primarily used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in organic synthesis and as an intermediate in the production of various chemicals. Methyl 6-(chloromethyl)pyridine-2-carboxylate is known for its strong reactivity and is commonly handled and used in laboratory settings with caution and proper safety measures.

InChI:InChI=1/C8H8ClNO2/c1-12-8(11)7-4-2-3-6(5-9)10-7/h2-4H,5H2,1H3

Upstream product

• 39977-44-1 methyl 6-(hydroxymethyl)pyridine-2-carboxylate 
• 5453-67-8 2,6-bis(methoxycarbonyl)pyridine 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 13602-11-4 6-methylpicolinic acid methyl ester 
• 934-60-1 6-methyl-2-pyridinecarboxylic acid 
• 126125-54-0 6-methyl-pyridine-2-carbonyl chloride 

Downstream Products

• 49715-22-2 6-(chloromethyl)-2-pyridinecarboxylic acid 
• 1055927-07-5 6-((4-methylpiperazin-1-yl)methyl)picolinic acid 

Relevant articles and documents

Monopicolinate cyclen and cyclam derivatives for stable copper(II) complexation

The syntheses of a new 1,4,7,10-tetraazacyclododecane (cyclen) derivative bearing a picolinate pendant arm (HL1), and its 1,4,8,11- tetraazacyclotetradecane (cyclam) analogue HL2, were achieved by using two different selective-protection methods involving the preparation of cyclen-bisaminal or phosphoryl cyclam derivatives. The acid-base properties of both compounds were investigated as well as their coordination chemistry, especially with Cu2+, in aqueous solution and in solid state. The copper(II) complexes were synthesized, and the single crystal X-ray diffraction structures of compounds of formula [Cu(HL)](ClO4)2· H2O (L = L1 or L2), [CuL1](ClO4) and [CuL2] Cl·2H2O, were determined. These studies revealed that protonation of the complexes occurs on the carboxylate group of the picolinate moiety. Stability constants of the complexes were determined at 25.0 °C and ionic strength 0.10 M in KNO3 using potentiometric titrations. Both ligands form complexes with Cu2+ that are thermodynamically very stable. Additionally, both HL1 and HL2 exhibit an important selectivity for Cu2+ over Zn2+. The kinetic inertness in acidic medium of both complexes of Cu2+ was evaluated by spectrophotometry revealing that [CuL2]+ is much more inert than [CuL1]+. The determined half-life values also demonstrate the very high kinetic inertness of [CuL2]+ when compared to a list of copper(II) complexes of other macrocyclic ligands. The coordination geometry of the copper center in the complexes was established in aqueous solution from UV-visible and electron paramagnetic resonance (EPR) spectroscopy, showing that the solution structures of both complexes are in excellent agreement with those of crystallographic data. Cyclic voltammetry experiments point to a good stability of the complexes with respect to metal ion dissociation upon reduction of the metal ion to Cu+ at about neutral pH. Our results revealed that the cyclam-based ligand HL2 is a very attractive receptor for copper(II), presenting a fast complexation process, a high kinetic inertness, and important thermodynamic and electrochemical stability.

OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS

The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuconate semialdehyde decarboxylase (ACMSD).

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.