220077-24-7 Usage
General Description
(5S)-N-(tert-Butoxycarbonyl)-3,4,5,6-tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one is a chemical compound that belongs to the oxazin-2-one family. It is a white crystalline solid that is commonly used in organic synthesis and pharmaceutical research. (5S)-N-(tert-Butoxycarbonyl)-3,4,5,6-tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one has a tetrahydrooxazine ring, which is typically found in various natural products and pharmaceuticals. The tert-Butoxycarbonyl (Boc) protecting group on the nitrogen atom allows for the selective modification of the molecule during synthetic processes. (5S)-N-(tert-Butoxycarbonyl)-3,4,5,6-tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one is also known for its potential biological activities and is the subject of ongoing research for its potential applications in medicine and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 220077-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,0,7 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 220077-24:
(8*2)+(7*2)+(6*0)+(5*0)+(4*7)+(3*7)+(2*2)+(1*4)=87
87 % 10 = 7
So 220077-24-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H19NO4/c1-15(2,3)20-14(18)16-9-13(17)19-10-12(16)11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3/t12-/m1/s1
220077-24-7Relevant articles and documents
A mild approach to synthesise enantiopure glycine-derived 5-phenylthiomorpholinone
Monir, Diana K.,Harwood, Laurence M.
, (2021/03/04)
A seven-step synthetic route has been developed to access the labile C-3 unsubstituted 5-phenylthiomorpholinone system for the first time. The key step involved the nucleophilic ring opening of Boc-phenylmorpholinone to give the corresponding methyl ester. The sulfur introduction was accomplished through a Mitsunobu reaction to yield a thioacetate, which was then hydrolysed to provide the thiol acid. Cyclization of the thiol acid was achieved using DCC in the presence of DMAP, to give Boc-phenylthiomorpholinone and subsequent deprotection afforded the elusive C-3 unsubstituted 5-phenylthiomorpholinone.
STEREOSELECTIVE ALKYLATION OF CHIRAL GLYCINE ENOLATE SYNTHONS. THE ENANTIOSELECTIVE SYNTHESIS O α-AMINO ACID DERIVATES
Dellaria, Joseph F.,Santarsiero, Bernard D.
, p. 6079 - 6082 (2007/10/02)
The highly stereoselective alkylation (percentde=99.6 to 97.6) o a new chiral glycine enolate synthon derived from D-2-phenylglycinol is described.Deprotection of the alkylation adducts in a one-pot, three-step procedure provides the ethyl ester hydrochloride salts of the corresponding α-amino acids with no attending racemization.
