220089-24-7 Usage
Description
(R)-(+)-1-(4-iodophenyl)ethanol, also known as 4-Iodo-α-methylbenzyl alcohol, is a chiral chemical compound with the molecular formula C8H9IO. It is a white solid at room temperature and is recognized for its ability to participate in various chemical reactions, making it a valuable resource in the field of organic chemistry.
Uses
Used in Pharmaceutical Synthesis:
(R)-(+)-1-(4-iodophenyl)ethanol is used as a versatile building block for the synthesis of various pharmaceuticals and fine chemicals. Its unique structure and reactivity contribute to the development of new and improved medications.
Used in Chiral Ligand Synthesis:
In the field of asymmetric synthesis, (R)-(+)-1-(4-iodophenyl)ethanol is used as a reagent in the synthesis of chiral ligands. These ligands are essential for creating enantiomerically pure compounds, which are crucial in the pharmaceutical industry due to their different biological activities.
Used in Chiral Biaryl Compound Preparation:
(R)-(+)-1-(4-iodophenyl)ethanol also serves as a precursor in the preparation of various chiral biaryl compounds. These compounds have applications in multiple industries, including pharmaceuticals, agrochemicals, and materials science, where their unique properties are harnessed for specific uses.
Used in Organic Chemistry Research:
Due to its ability to undergo numerous chemical reactions, (R)-(+)-1-(4-iodophenyl)ethanol is a valuable resource for researchers in organic chemistry. It can be used to explore new reaction pathways, develop novel synthetic methods, and study the effects of chirality on chemical behavior.
Check Digit Verification of cas no
The CAS Registry Mumber 220089-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,0,8 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 220089-24:
(8*2)+(7*2)+(6*0)+(5*0)+(4*8)+(3*9)+(2*2)+(1*4)=97
97 % 10 = 7
So 220089-24-7 is a valid CAS Registry Number.
220089-24-7Relevant articles and documents
Manganese catalyzed asymmetric transfer hydrogenation of ketones
Zhang, Guang-Ya,Ruan, Sun-Hong,Li, Yan-Yun,Gao, Jing-Xing
supporting information, p. 1415 - 1418 (2020/11/20)
The asymmetric transfer hydrogenation (ATH) of a wide range of ketones catalyzed by manganese complex as well as chiral PxNy-type ligand under mild conditions was investigated. Using 2-propanol as hydrogen source, various ketones could be enantioselectively hydrogenated by combining cheap, readily available [MnBr(CO)5] with chiral, 22-membered macrocyclic ligand (R,R,R',R')-CyP2N4 (L5) with 2 mol% of catalyst loading, affording highly valuable chiral alcohols with up to 95% ee.
Asymmetric transfer hydrogenation of ketones promoted by manganese(I) pre-catalysts supported by bidentate aminophosphines
Azouzi, Karim,Bruneau-Voisine, Antoine,Vendier, Laure,Sortais, Jean-Baptiste,Bastin, Stéphanie
, (2020/05/19)
A series of commercially available chiral amino-phosphines, in combination with Mn(CO)5Br, has been evaluated for the asymmetric reduction of ketones, using isopropanol as hydrogen source. With the most selective ligand, the corresponding manga
RETRACTED ARTICLE: The Manganese(I)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones: Disclosing the Macrocylic Privilege
Passera, Alessandro,Mezzetti, Antonio
supporting information, p. 187 - 191 (2019/12/11)
The bis(carbonyl) manganese(I) complex [Mn(CO)2(1)]Br (2) with a chiral (NH)2P2 macrocyclic ligand (1) catalyzes the asymmetric transfer hydrogenation of polar double bonds with 2-propanol as the hydrogen source. Ketones (43 substrates) are reduced to alcohols in high yields (up to >99 %) and with excellent enantioselectivities (90–99 % ee). A stereochemical model based on attractive CH–π interactions is proposed.
